{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:34:47Z","timestamp":1790786087737,"version":"4.1.0"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2021,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The objective of this study was to evaluate the effect of vitamin D<jats:sub>3<\/jats:sub> on total homocysteine (tHcy) and C-reactive protein (CRP) levels and liver and kidney function tests in overweight women with vitamin D deficiency. Therefore, a randomised, double-blind placebo, controlled clinical trial was conducted on 100 eligible women. Subjects were randomly divided into two groups: the placebo (<jats:italic>n<\/jats:italic> 50) and the vitamin D (<jats:italic>n<\/jats:italic> 50) which received 1250 \u00b5g vitamin D<jats:sub>3<\/jats:sub> per week for 2 months. The participants\u2019 25-hydroxyvitamin D (25(OH)D), tHcy, CRP, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea, creatinine and estimated glomerular filtration rate (eGFR) were measured and compared before and after treatment. Results showed that the tHcy, CRP, AST, ALT and eGFR levels after the 2nd month of vitamin D<jats:sub>3<\/jats:sub> intervention were significantly (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001) decreased and the 25(OH)D, urea and creatinine levels were significantly (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001) increased in the treatment group. In the placebo group, no significant changes were identified throughout the follow-up period. In conclusion, vitamin D<jats:sub>3<\/jats:sub> intervention with a treatment dose of 1250 \u00b5g\/week for at least 2 months may help in lowering Hcy and CRP levels and may improve liver function tests, which in turn might help in minimising the risk of CVD and liver diseases among overweight women but negatively affect kidney function.<\/jats:p>","DOI":"10.1017\/s0007114520001890","type":"journal-article","created":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T08:18:22Z","timestamp":1590999502000},"page":"139-146","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":21,"title":["Vitamin D<sub>3<\/sub> reduces risk of cardiovascular and liver diseases by lowering homocysteine levels: double-blinded, randomised, placebo-controlled trial"],"prefix":"10.1017","volume":"125","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-4402","authenticated-orcid":false,"given":"N.","family":"Al-Bayyari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Hailat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Subih","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Alkhalidy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Eaton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2020,6,1]]},"reference":[{"key":"S0007114520001890_ref30","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2013-3262"},{"key":"S0007114520001890_ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131740"},{"key":"S0007114520001890_ref3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCOUTCOMES.112.967604"},{"key":"S0007114520001890_ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00732.x"},{"key":"S0007114520001890_ref44","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfy074"},{"key":"S0007114520001890_ref46","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.04960514"},{"key":"S0007114520001890_ref50","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.10.1805"},{"key":"S0007114520001890_ref23","first-page":"83","volume-title":"Statistical Methods","author":"Snedecor","year":"1980"},{"key":"S0007114520001890_ref5","first-page":"14977","article-title":"A meta-analysis of the relationship between vitamin D deficiency and obesity","volume":"8","author":"Yao","year":"2015","journal-title":"Int J Clin Exp Med"},{"key":"S0007114520001890_ref29","doi-asserted-by":"publisher","DOI":"10.1111\/jch.12881"},{"key":"S0007114520001890_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-139X.2005.18402.x"},{"key":"S0007114520001890_ref14","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i7.922"},{"key":"S0007114520001890_ref16","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.1.18"},{"key":"S0007114520001890_ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.acvd.2009.07.002"},{"key":"S0007114520001890_ref27","doi-asserted-by":"publisher","DOI":"10.1159\/000180580"},{"key":"S0007114520001890_ref28","doi-asserted-by":"publisher","DOI":"10.1080\/08860220701810554"},{"key":"S0007114520001890_ref12","doi-asserted-by":"publisher","DOI":"10.3390\/nu6062206"},{"key":"S0007114520001890_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2012.04.001"},{"key":"S0007114520001890_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2013.11.003"},{"key":"S0007114520001890_ref25","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0138"},{"key":"S0007114520001890_ref43","unstructured":"43. National Institutes of Health (NIH) (2017) Creatinine blood test. U.S. National Library of Medicine. https:\/\/medlineplus.gov\/ency\/article\/003475.htm (accessed April 2020)."},{"key":"S0007114520001890_ref42","doi-asserted-by":"publisher","DOI":"10.1186\/s12937-016-0221-6"},{"key":"S0007114520001890_ref6","doi-asserted-by":"publisher","DOI":"10.5114\/aoms.2017.68237"},{"key":"S0007114520001890_ref47","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.03830415"},{"key":"S0007114520001890_ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0161368"},{"key":"S0007114520001890_ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-0107-8"},{"key":"S0007114520001890_ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-010-0361-5"},{"key":"S0007114520001890_ref41","doi-asserted-by":"publisher","DOI":"10.3390\/nu9080806"},{"key":"S0007114520001890_ref35","doi-asserted-by":"publisher","DOI":"10.1038\/embor.2011.65"},{"key":"S0007114520001890_ref19","doi-asserted-by":"crossref","first-page":"24","DOI":"10.4103\/ijpvm.IJPVM_37_18","article-title":"Association of serum 25-hydroxyvitamin D levels and liver enzymes in a nationally representative sample of Iranian adolescents: the childhood and adolescence surveillance and prevention of adult noncommunicable disease study","volume":"9","author":"Bahreynian","year":"2018","journal-title":"Int J Prev Med"},{"key":"S0007114520001890_ref49","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1755.1999.0550031028.x"},{"key":"S0007114520001890_ref48","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.207"},{"key":"S0007114520001890_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpt160"},{"key":"S0007114520001890_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-011-0981-y"},{"key":"S0007114520001890_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/ncpcardio1322"},{"key":"S0007114520001890_ref36","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-00796-3"},{"key":"S0007114520001890_ref32","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6236309"},{"key":"S0007114520001890_ref2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.4.1080S"},{"key":"S0007114520001890_ref40","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15102064"},{"key":"S0007114520001890_ref15","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2011.02735.x"},{"key":"S0007114520001890_ref11","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2016.37"},{"key":"S0007114520001890_ref38","first-page":"221","article-title":"1","volume":"11","author":"Koli","year":"2000","journal-title":"Cell Growth Differ"},{"key":"S0007114520001890_ref39","doi-asserted-by":"publisher","DOI":"10.3390\/biology8020030"},{"key":"S0007114520001890_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2018.07.012"},{"key":"S0007114520001890_ref31","doi-asserted-by":"publisher","DOI":"10.4070\/kcj.2016.0198"},{"key":"S0007114520001890_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2017.10.008"},{"key":"S0007114520001890_ref34","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.684399"},{"key":"S0007114520001890_ref37","doi-asserted-by":"publisher","DOI":"10.3390\/nu7105392"},{"key":"S0007114520001890_ref26","first-page":"705","volume-title":"Labor und Diagnose: Indikation und Bewertung von Laborbefunden f\u00fcr die medizinische Diagnostik (Laboratory and Diagnosis: Indication and Evaluation of Laboratory Results for Medical Diagnosis)","author":"Herrmann","year":"2012"},{"key":"S0007114520001890_ref45","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2013.03.010"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114520001890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T07:25:50Z","timestamp":1638775550000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114520001890\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6,1]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,1,28]]}},"alternative-id":["S0007114520001890"],"URL":"https:\/\/doi.org\/10.1017\/s0007114520001890","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,6,1]]},"assertion":[{"value":"\u00a9 The Author(s), 2020","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}