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The present study evaluated the effects of plant extracts on lipid droplet accumulation and the growth of probiotics <jats:italic>in vitro<\/jats:italic>. A C57BL\/6 mouse model was used to examine the effects of probiotics and plant extracts on NAFLD. Body weight and food intake were measured. The levels of serum lipids, oxidative stress and the liver injury index were determined using commercial kits. Haematoxylin and eosin staining, GC and real-time PCR were also used for analysis. The results revealed that administration of <jats:italic>Lactobacillus casei<\/jats:italic> YRL577 and <jats:italic>L. paracasei<\/jats:italic> X11 with resveratrol (RES) or tea polyphenols (TP) significantly reduced the levels of total cholesterol, TAG and LDL-cholesterol and increased the level of the HDL-cholesterol. The groups of <jats:italic>L. casei<\/jats:italic> YRL577 with RES and TP also regulated the liver structure, oxidative stress and injury. Furthermore, <jats:italic>L. casei<\/jats:italic> YRL577 with TP exhibited a more positive effect towards improving the NAFLD and increased the concentrations of the butyric acid than other three combined groups. <jats:italic>L. casei<\/jats:italic> YRL577 with TP up-regulated the mRNA levels of the farnesoid X receptor and fibroblast growth factor 15 and decreased the mRNA levels of the apical Na-dependent bile acid transporter. These findings showed that <jats:italic>L. casei<\/jats:italic> YRL577 + TP-modified genes in the intestinal bile acid pathway improved markers of NAFLD.<\/jats:p>","DOI":"10.1017\/s0007114520003013","type":"journal-article","created":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T03:48:49Z","timestamp":1595908129000},"page":"1081-1091","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["<i>Lactobacillus casei<\/i> YRL577 combined with plant extracts reduce markers of non-alcoholic fatty liver disease in 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