{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:14:53Z","timestamp":1768742093038,"version":"3.49.0"},"reference-count":58,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T00:00:00Z","timestamp":1599004800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2021,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Replacing intake of SFA with PUFA reduces serum cholesterol levels and CVD risk. The effect on glycaemic regulation is, however, less clear. The main objective of the present study was to investigate the short-term effect of replacing dietary SFA with PUFA on glycaemic regulation. Seventeen healthy, normal-weight participants completed a 25-d double-blind, randomised and controlled two-period crossover study. Participants were allocated to either interventions with PUFA products or SFA products (control) in a random order for three consecutive days, separated by a 1\u00b75-week washout period between the intervention periods. Glucose, insulin and TAG were measured before and after an oral glucose tolerance test. In addition, fasting total cholesterol, NEFA and plasma total fatty acid profile were measured before and after the 3-d interventions. Fasting and postprandial glucose, insulin, and TAG levels and fasting levels of NEFA and plasma fatty acid profile did not differ between the groups. However, replacing dietary SFA with PUFA significantly reduced total cholesterol levels by 8 % after 3 d (<jats:italic>P<\/jats:italic> = 0\u00b7002). Replacing dietary SFA with PUFA for only 3 d has beneficial cardio-metabolic effects by reducing cholesterol levels in healthy individuals.<\/jats:p>","DOI":"10.1017\/s0007114520003402","type":"journal-article","created":{"date-parts":[[2020,9,2]],"date-time":"2020-09-02T04:37:06Z","timestamp":1599021426000},"page":"915-925","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":20,"title":["Beneficial effect on serum cholesterol levels, but not glycaemic regulation, after replacing SFA with PUFA for 3 d: a randomised crossover trial"],"prefix":"10.1017","volume":"125","author":[{"given":"Line","family":"Gaundal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mari C. W.","family":"Myhrstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lena","family":"Leder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marte Gjeitung","family":"Byfuglien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terje","family":"Gj\u00f8vaag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida","family":"Rud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kjetil","family":"Retterst\u00f8l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten B.","family":"Holven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stine M.","family":"Ulven","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0874-1420","authenticated-orcid":false,"given":"Vibeke H.","family":"Telle-Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2020,9,2]]},"reference":[{"key":"S0007114520003402_ref56","doi-asserted-by":"publisher","DOI":"10.1097\/00043798-199604000-00014"},{"key":"S0007114520003402_ref3","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114516003445"},{"key":"S0007114520003402_ref2","doi-asserted-by":"publisher","DOI":"10.3390\/nu8030173"},{"key":"S0007114520003402_ref43","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.10.013"},{"key":"S0007114520003402_ref51","doi-asserted-by":"publisher","DOI":"10.3945\/jn.113.183749"},{"key":"S0007114520003402_ref41","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD011094.pub4"},{"key":"S0007114520003402_ref40","first-page":"897","article-title":"NNR 2012: Nordic Nutrition Recommendations\u2014integrating nutrition and physical activity","volume":"63","author":"Becker","year":"2013","journal-title":"Ann Nutr Metab"},{"key":"S0007114520003402_ref55","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.20045"},{"key":"S0007114520003402_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)31510-8"},{"key":"S0007114520003402_ref29","volume-title":"WHO Guidelines on Drawing Blood: Best Practices in Phlebotomy","year":"2010"},{"key":"S0007114520003402_ref28","doi-asserted-by":"publisher","DOI":"10.1007\/s001250051620"},{"key":"S0007114520003402_ref25","doi-asserted-by":"publisher","DOI":"10.1530\/JME-17-0195"},{"key":"S0007114520003402_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.5.1628S"},{"key":"S0007114520003402_ref12","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.24.9.1528"},{"key":"S0007114520003402_ref53","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2796.1999.00548.x"},{"key":"S0007114520003402_ref11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.010236"},{"key":"S0007114520003402_ref57","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201600465R"},{"key":"S0007114520003402_ref4","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2001.10719008"},{"key":"S0007114520003402_ref19","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000163185.28245.a1"},{"key":"S0007114520003402_ref14","doi-asserted-by":"publisher","DOI":"10.1136\/bmjdrc-2018-000585"},{"key":"S0007114520003402_ref8","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.110.004622"},{"key":"S0007114520003402_ref1","unstructured":"1. World Health Organization (2018) Top 10 Causes of Death. http:\/\/www.who.int\/mediacentre\/factsheets\/fs310\/en\/ (accessed February 2020)."},{"key":"S0007114520003402_ref5","doi-asserted-by":"publisher","DOI":"10.3402\/fnr.v58.25145"},{"key":"S0007114520003402_ref35","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.22.9.1462"},{"key":"S0007114520003402_ref22","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/49.3.448"},{"key":"S0007114520003402_ref33","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/84.1.54"},{"key":"S0007114520003402_ref54","doi-asserted-by":"publisher","DOI":"10.2174\/157340309788970315"},{"key":"S0007114520003402_ref13","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.6.1019"},{"key":"S0007114520003402_ref36","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/65.1.79"},{"key":"S0007114520003402_ref49","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2019.25"},{"key":"S0007114520003402_ref30","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0b013e3181ed61a3"},{"key":"S0007114520003402_ref42","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.12.011"},{"key":"S0007114520003402_ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2011.01.001"},{"key":"S0007114520003402_ref46","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.011590"},{"key":"S0007114520003402_ref18","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.097089"},{"key":"S0007114520003402_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsams.2011.04.003"},{"key":"S0007114520003402_ref6","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000252"},{"key":"S0007114520003402_ref34","doi-asserted-by":"publisher","DOI":"10.1007\/BF00280883"},{"key":"S0007114520003402_ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-001-0768-3"},{"key":"S0007114520003402_ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.047"},{"key":"S0007114520003402_ref23","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508894408"},{"key":"S0007114520003402_ref31","doi-asserted-by":"publisher","DOI":"10.1249\/01.mss.0000185674.09066.8a"},{"key":"S0007114520003402_ref37","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.030114"},{"key":"S0007114520003402_ref52","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1097\/MOL.0000000000000381","article-title":"Milk fat biomarkers and cardiometabolic disease","volume":"28","author":"Riserus","year":"2017","journal-title":"Curr Opin Lipidol"},{"key":"S0007114520003402_ref17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002087"},{"key":"S0007114520003402_ref50","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2009.28586"},{"key":"S0007114520003402_ref27","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114515002524"},{"key":"S0007114520003402_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-010-3393-4"},{"key":"S0007114520003402_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/77.5.1146"},{"key":"S0007114520003402_ref44","doi-asserted-by":"publisher","DOI":"10.1097\/MOL.0000000000000646"},{"key":"S0007114520003402_ref7","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27124"},{"key":"S0007114520003402_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.02.016"},{"key":"S0007114520003402_ref58","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2011.00401.x"},{"key":"S0007114520003402_ref21","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2013.077222"},{"key":"S0007114520003402_ref47","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/135.11.2503"},{"key":"S0007114520003402_ref24","doi-asserted-by":"publisher","DOI":"10.3390\/nu11051067"},{"key":"S0007114520003402_ref39","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.114.001095"},{"key":"S0007114520003402_ref48","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.001602"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114520003402","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T01:34:51Z","timestamp":1684114491000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114520003402\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,2]]},"references-count":58,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2021,4,28]]}},"alternative-id":["S0007114520003402"],"URL":"https:\/\/doi.org\/10.1017\/s0007114520003402","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,2]]},"assertion":[{"value":"\u00a9 The Author(s), 2020. Published by Cambridge University Press","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}