{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:08:33Z","timestamp":1789866513433,"version":"4.0.1"},"reference-count":69,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T00:00:00Z","timestamp":1607558400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2021,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Host\u2013microbial co-metabolism products are being increasingly recognised to play important roles in physiological processes. However, studies undertaking a comprehensive approach to consider host\u2013microbial metabolic relationships remain scarce. Metabolomic analysis yielding detailed information regarding metabolites found in a given biological compartment holds promise for such an approach. This work aimed to explore the associations between host plasma metabolomic signatures and gut microbiota composition in healthy adults of the <jats:italic>Milieu Int\u00e9rieur<\/jats:italic> study. For 846 subjects, gut microbiota composition was profiled through sequencing of the 16S rRNA gene in stools. Metabolomic signatures were generated through proton NMR analysis of plasma. The associations between metabolomic variables and <jats:italic>\u03b1<\/jats:italic>- and <jats:italic>\u03b2<\/jats:italic>-diversity indexes and relative taxa abundances were tested using multi-adjusted partial Spearman correlations, permutational ANOVA and multivariate associations with linear models, respectively. A multiple testing correction was applied (Benjamini\u2013Hochberg, 10 % false discovery rate). Microbial richness was negatively associated with lipid-related signals and positively associated with amino acids, choline, creatinine, glucose and citrate (\u22120\u00b7133 \u2264 Spearman\u2019s <jats:italic>\u03c1<\/jats:italic> \u2264 0\u00b7126). Specific associations between metabolomic signals and abundances of taxa were detected (twenty-five at the genus level and nineteen at the species level): notably, numerous associations were observed for creatinine (positively associated with eleven species and negatively associated with <jats:italic>Faecalibacterium prausnitzii<\/jats:italic>). This large-scale population-based study highlights metabolites associated with gut microbial features and provides new insights into the understanding of complex host\u2013gut microbiota metabolic relationships. In particular, our results support the implication of a \u2018gut\u2013kidney axis\u2019. More studies providing a detailed exploration of these complex interactions and their implications for host health are needed.<\/jats:p>","DOI":"10.1017\/s0007114520004870","type":"journal-article","created":{"date-parts":[[2020,12,10]],"date-time":"2020-12-10T10:33:25Z","timestamp":1607596405000},"page":"982-992","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Associations between untargeted plasma metabolomic signatures and gut microbiota composition in the <i>Milieu Int\u00e9rieur<\/i> population of healthy 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