{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T04:53:15Z","timestamp":1762145595368,"version":"3.40.5"},"reference-count":40,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T00:00:00Z","timestamp":1607904000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2021,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to examine whether baseline neutrophil counts affected the risk of new-onset proteinuria in hypertensive patients, and, if so, whether folic acid treatment is particularly effective in proteinuria prevention in such a setting. A total of 8208 eligible participants without proteinuria at baseline were analysed from the renal substudy of the China Stroke Primary Prevention Trial. Participants were randomised to receive a double-blind daily treatment of 10 mg of enalapril and 0\u00b78 mg of folic acid (<jats:italic>n<\/jats:italic> 4101) or 10 mg of enalapril only (<jats:italic>n<\/jats:italic> 4107). The primary outcome was new-onset proteinuria, defined as a urine dipstick reading of \u22651+ at the exit visit. The mean age of the participants was 59\u00b75 (<jats:sc>sd<\/jats:sc>, 7\u00b74) years, 3088 (37\u00b76 %) of the participants were male. The median treatment duration was 4\u00b74 years. In the enalapril-only group, a significantly higher risk of new-onset proteinuria was found among participants with higher neutrophil counts (quintile 5; \u22654\u00b78\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l, OR 1\u00b744; 95 % CI 1\u00b700, 2\u00b706), compared with those in quintiles 1\u20134. For those with enalapril and folic acid treatment, compared with the enalapril-only group, the new-onset proteinuria risk was reduced from 5\u00b72 to 2\u00b78 % (OR 0\u00b749; 95 % CI 0\u00b729, 0\u00b782) among participants with higher neutrophil counts (\u22654\u00b78\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l), whereas there was no significant effect among those with neutrophil counts &lt;4\u00b78\u00a0\u00d7\u00a010<jats:sup>9<\/jats:sup>\/l. In summary, among hypertensive patients, those with higher neutrophil counts had increased risk of new-onset proteinuria, and this risk was reduced by 51 % with folic acid treatment.<\/jats:p>","DOI":"10.1017\/s000711452000505x","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T08:11:15Z","timestamp":1607933475000},"page":"1040-1047","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Interaction of neutrophil counts and folic acid treatment on new-onset proteinuria in hypertensive 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