{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T01:57:39Z","timestamp":1760061459765},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T00:00:00Z","timestamp":1608681600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2021,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Maternal nutrition status plays an important role in the development of fetal alcohol spectrum disorders (FASD), but its direct evidence is lacking. This study compared a standard chow with a semi-purified energy-dense (E-dense) diet on birth and metabolic outcomes in rats after ethanol (EtOH) consumption during pregnancy. Pregnant Sprague\u2013Dawley rats were randomised into four groups: chow (<jats:italic>n<\/jats:italic> 6), chow\u00a0+\u00a0EtOH (20 %, v\/v) (<jats:italic>n<\/jats:italic> 7), E-dense (<jats:italic>n<\/jats:italic> 6) and E-dense\u00a0+\u00a0EtOH (<jats:italic>n<\/jats:italic> 8). Birth outcomes including litter size, body and organ weights were collected. Metabolic parameters were measured in dams and pups at postnatal day (PD) 7. Maternal EtOH consumption decreased body weights (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001) and litter sizes (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) in chow-fed dams. At PD7, pups born to dams fed the E-dense diet had higher body (<jats:italic>P<\/jats:italic> &lt; 0\u00b7002) and liver weights (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001). These pups also had higher plasma total cholesterol (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001), TAG (<jats:italic>P<\/jats:italic> &lt; 0\u00b7003) and alanine aminotransferase (<jats:italic>P<\/jats:italic> &lt; 0\u00b703) compared with those from chow-fed dams. Dams fed the E-dense diet had higher plasma total (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001) and HDL-cholesterol (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001) and lower glucose (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001). EtOH increased total cholesterol (<jats:italic>P<\/jats:italic> &lt; 0\u00b703) and glucose (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) only in dams fed the E-dense diet. Maternal exposure to the E-dense diet attenuated prenatal EtOH-induced weight loss and produced different metabolic outcomes in both dams and pups. While the long-lasting effects of these outcomes are unknown, this study highlights the importance of maternal diet quality for maternal health and infant growth and suggests that maternal nutrition intervention may be a potential target for alleviating FASD.<\/jats:p>","DOI":"10.1017\/s0007114520005152","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T10:48:50Z","timestamp":1608720530000},"page":"1130-1139","update-policy":"http:\/\/dx.doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Differential effects of maternal diets on birth outcomes and metabolic parameters in rats after ethanol consumption during pregnancy"],"prefix":"10.1017","volume":"126","author":[{"given":"Yidi","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bradley A.","family":"Feltham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael N. 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