{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T07:46:10Z","timestamp":1794469570918,"version":"4.9.1"},"reference-count":32,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T00:00:00Z","timestamp":1611619200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2021,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Folic acid (FA) can reduce the risk for selected birth defects other than neural tube defects. We examined whether FA has preventive effects against fetal abdominal wall defects (AWD) in a unique intervention cohort in China. Birth outcomes of 247\u00a0831 singleton births from a population-based cohort study with detailed pre-conceptional FA intake information were collected in China in 1993\u20131996. Information on births at 20 complete gestational weeks, including live births, stillbirths and pregnancy terminations, and all structural birth defects regardless of gestational week were recorded. The birth prevalence of omphalocele, gastroschisis and total fetal AWD was classified by maternal FA supplementation. The prevalence of total AWD was 4\u00b730 per 10\u00a0000 births among women who took FA compared with 13\u00b746 per 10\u00a0000 births among those who did not take FA in northern China and 6\u00b728 and 5\u00b718 per 10\u00a0000 births, respectively, in southern China. The prevalence of omphalocele was 0\u00b754 per 10\u00a0000 births among women who took FA compared with 3\u00b774 per 10\u00a0000 births among those who did not take FA in northern China and 1\u00b779 and 1\u00b744 per 10\u00a0000 births, respectively, in southern China. FA supplementation significantly prevented total AWD in multivariate analysis (relative risk 0\u00b726, 95 % CI 0\u00b711, 0\u00b761) in northern China, although no preventive effect of FA on AWD was observed in southern China. FA supplementation successfully reduced the prevalence of AWD in northern China.<\/jats:p>","DOI":"10.1017\/s0007114521000337","type":"journal-article","created":{"date-parts":[[2021,1,26]],"date-time":"2021-01-26T04:08:21Z","timestamp":1611634101000},"page":"1558-1563","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Folic acid supplementation and risk for fetal abdominal wall defects in China: results from a large population-based intervention cohort study"],"prefix":"10.1017","volume":"126","author":[{"given":"Jufen","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongwei","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiguo","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3220-6084","authenticated-orcid":false,"given":"Jianmeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,1,26]]},"reference":[{"key":"S0007114521000337_ref26","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dys092"},{"key":"S0007114521000337_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32297"},{"key":"S0007114521000337_ref13","first-page":"282","article-title":"Epidemiology and outcome of major congenital malformations in a large German county","volume":"29","author":"Wittekindt","year":"2018","journal-title":"Eur J Pediatr Surg"},{"key":"S0007114521000337_ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1988.tb03478.x"},{"key":"S0007114521000337_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-3995(01)01094-2"},{"key":"S0007114521000337_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyz130"},{"key":"S0007114521000337_ref16","first-page":"424","article-title":"Course of congenital malformation incidences and their changes over time in children born in the Czech Republic","volume":"77","author":"Sipek","year":"2012","journal-title":"Ceska Gynekologie"},{"key":"S0007114521000337_ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2018.11.011"},{"key":"S0007114521000337_ref18","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1025"},{"key":"S0007114521000337_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20210"},{"key":"S0007114521000337_ref4","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200211000-00005"},{"key":"S0007114521000337_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/154.11.1051"},{"key":"S0007114521000337_ref25","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-3016.2003.00478.x"},{"key":"S0007114521000337_ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199212243272602"},{"key":"S0007114521000337_ref24","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu020"},{"key":"S0007114521000337_ref14","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2017.07.004"},{"key":"S0007114521000337_ref23","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30772"},{"key":"S0007114521000337_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412001"},{"key":"S0007114521000337_ref29","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520001178"},{"key":"S0007114521000337_ref3","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0b013e31824d0349"},{"key":"S0007114521000337_ref9","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-011-1117-3"},{"key":"S0007114521000337_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpobgyn.2013.10.003"},{"key":"S0007114521000337_ref7","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.5.904"},{"key":"S0007114521000337_ref19","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015-0017"},{"key":"S0007114521000337_ref30","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980007246786"},{"key":"S0007114521000337_ref22","doi-asserted-by":"publisher","DOI":"10.1007\/s10029-019-01971-3"},{"key":"S0007114521000337_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.61830"},{"key":"S0007114521000337_ref20","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23349"},{"key":"S0007114521000337_ref32","unstructured":"32. 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