{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T21:12:34Z","timestamp":1783113154733,"version":"3.54.6"},"reference-count":49,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T00:00:00Z","timestamp":1612742400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2021,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    High dietary phosphorus (P), particularly soluble salts, may contribute to chronic kidney disease development in cats. The aim of the present study was to assess the safety of P supplied at 1 g\/1000 kcal (4184kJ) from a highly soluble P salt in P-rich dry format feline diets. Seventy-five healthy adult cats (\n                    <jats:italic>n<\/jats:italic>\n                    25\/group) were fed either a low P control (1\u00b74 g\/1000 kcal [4184kJ]; Ca:P ratio 0\u00b797) or one of two test diets with 4 g\/1000 kcal (4184 kJ); Ca:P 1\u00b704 or 5 g\/1000 kcal (4184kJ); Ca:P 1\u00b727, both incorporating 1 g\/1000 kcal (4184 kJ) sodium tripolyphosphate (STPP) \u2013 for a period of 30 weeks in a randomised parallel-group study. Health markers in blood and urine, glomerular filtration rate, renal ultrasound and bone density were assessed at baseline and at regular time points. At the end of the test period, responses following transition to a commercial diet (total P \u2013 2\u00b734 g\/1000 kcal [4184kJ], Ca:P 1\u00b73) for a 4-week washout period were also assessed. No adverse effects on general, kidney or bone (skeletal) function and health were observed. P and Ca balance, some serum biochemistry parameters and regulatory hormones were increased in cats fed test diets from week 2 onwards (\n                    <jats:italic>P<\/jats:italic>\n                    \u2264 0\u00b705). Data from the washout period suggest that increased serum creatinine and urea values observed in the two test diet groups were influenced by dietary differences during the test period, and not indicative of changes in renal function. The present data suggest no observed adverse effect level for feline diets containing 1 g P\/1000 kcal (4184 kJ) from STPP and total P level of up to 5 g\/1000 kcal (4184 kJ) when fed for 30 weeks.\n                  <\/jats:p>","DOI":"10.1017\/s0007114521000477","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T03:20:11Z","timestamp":1612754411000},"page":"1626-1641","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["Towards establishing no observed adverse effect levels (NOAEL) for different sources of dietary phosphorus in feline adult diets: results from a 7-month feeding study"],"prefix":"10.1017","volume":"126","author":[{"given":"Jennifer C.","family":"Coltherd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet E.","family":"Alexander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Pink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Rawlings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Haydock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura J.","family":"Carvell-Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent C.","family":"Biourge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Molina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Butterwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren W.","family":"Logan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Watson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Marie","family":"Bakke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,2,8]]},"reference":[{"key":"S0007114521000477_ref17","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.2012.01253.x"},{"key":"S0007114521000477_ref6","first-page":"1334","article-title":"Increasing phosphorus intake reduces urinary concentrations of magnesium and calcium in adult ovariectomized cats fed purified diets","volume":"125","author":"Pastoor","year":"1995","journal-title":"J Nutr"},{"key":"S0007114521000477_ref27","doi-asserted-by":"publisher","DOI":"10.1177\/1098612X18757591"},{"key":"S0007114521000477_ref7","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518003379"},{"key":"S0007114521000477_ref20","first-page":"48","article-title":"Fitting linear mixed-effects models using lme4","volume":"2015","author":"Bates","year":"2015","journal-title":"J Stat Softw"},{"key":"S0007114521000477_ref29","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.V24856"},{"key":"S0007114521000477_ref47","doi-asserted-by":"publisher","DOI":"10.1080\/10408690091189194"},{"key":"S0007114521000477_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.rvsc.2004.02.007"},{"key":"S0007114521000477_ref21","doi-asserted-by":"publisher","DOI":"10.1002\/bimj.200810425"},{"key":"S0007114521000477_ref34","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.11.070191.001323"},{"key":"S0007114521000477_ref48","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12074"},{"key":"S0007114521000477_ref4","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-071816-064607"},{"key":"S0007114521000477_ref2","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114518002751"},{"key":"S0007114521000477_ref24","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153653"},{"key":"S0007114521000477_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfms.2011.05.019"},{"key":"S0007114521000477_ref39","doi-asserted-by":"publisher","DOI":"10.2460\/javma.2001.219.1228"},{"key":"S0007114521000477_ref22","doi-asserted-by":"publisher","DOI":"10.1111\/jvim.12446"},{"key":"S0007114521000477_ref25","doi-asserted-by":"publisher","DOI":"10.1620\/tjem.224.137"},{"key":"S0007114521000477_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/132.6.1637S"},{"key":"S0007114521000477_ref28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-5827.1998.tb03598.x"},{"key":"S0007114521000477_ref8","unstructured":"8. 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Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}