{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T01:02:53Z","timestamp":1791248573858,"version":"4.1.0"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T00:00:00Z","timestamp":1613692800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2021,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin B<jats:sub>12<\/jats:sub> (B<jats:sub>12<\/jats:sub>) is a co-enzyme essential for fetal growth and development. Lower maternal B<jats:sub>12<\/jats:sub> status has been associated with preterm birth (&lt;37 gestational weeks) and low birth weight (&lt;2500 g), which are linked to morbidity and mortality across the lifespan. In Canada, 17\u201325 % of women in early pregnancy had a serum total B<jats:sub>12<\/jats:sub> concentration &lt;148 pmol\/l and maternal total B<jats:sub>12<\/jats:sub> concentration decreased throughout pregnancy. This study aimed to determine the association between maternal B<jats:sub>12<\/jats:sub> status and birth outcomes in Canadian mother\u2013newborn dyads. A secondary analysis of 709 mother\u2013newborn dyads in British Columbia (BC), Canada, was conducted. Bio-banked first- (<jats:italic>n<\/jats:italic> 656) and second-trimester (<jats:italic>n<\/jats:italic> 709) maternal serum samples of apparently healthy South Asian (50 %) and European (50 %) women from the BC Prenatal Genetic Screening Program were quantified for B<jats:sub>12<\/jats:sub> biomarkers (total B<jats:sub>12<\/jats:sub>, holotranscobalamin (holoTC), methylmalonic acid (MMA) and total homocysteine (tHcy)). Obstetric history and birth outcome data were obtained from the BC Perinatal Data Registry. All associations were determined using multiple linear regression. Maternal serum total B<jats:sub>12<\/jats:sub>, holoTC, MMA and tHcy had a mean weekly decrease of 3\u00b764 pmol\/l, 1\u00b704 pmol\/l, 1\u00b744 nmol\/l and 0\u00b7104 \u03bcmol\/l, respectively (<jats:italic>P<\/jats:italic> &lt; 0\u00b7001). Despite a total B<jats:sub>12<\/jats:sub> concentration &lt;148 pmol\/l among 20\u201325 % of the women, maternal B<jats:sub>12<\/jats:sub> biomarker concentrations were not associated with birth weight <jats:italic>z<\/jats:italic>-score, head circumference <jats:italic>z<\/jats:italic>-score and gestational age at birth (<jats:italic>P<\/jats:italic> &gt; 0\u00b705). Additional research in women at high risk of adverse birth outcomes and the association between maternal B<jats:sub>12<\/jats:sub> status and functional, for example, cognitive, outcomes is needed.<\/jats:p>","DOI":"10.1017\/s0007114521000581","type":"journal-article","created":{"date-parts":[[2021,2,19]],"date-time":"2021-02-19T06:56:17Z","timestamp":1613717777000},"page":"1823-1831","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":14,"title":["Maternal vitamin B<sub>12<\/sub> status in early pregnancy and its association with birth outcomes in Canadian mother\u2013newborn Dyads"],"prefix":"10.1017","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1361-201X","authenticated-orcid":false,"given":"Amy","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Sinclair","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Mattman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary D.","family":"Vallance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvonne","family":"Lamers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,2,19]]},"reference":[{"key":"S0007114521000581_ref39","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/nqx041"},{"key":"S0007114521000581_ref32","unstructured":"32. World Health Organization (2000) Obesity: preventing and managing the global epidemic [Internet]. https:\/\/www.who.int\/nutrition\/publications\/obesity\/WHO_TRS_894\/en\/ (accessed August 2019)."},{"key":"S0007114521000581_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(93)90010-L"},{"key":"S0007114521000581_ref31","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S129785"},{"key":"S0007114521000581_ref10","doi-asserted-by":"publisher","DOI":"10.1038\/ejcn.2013.289"},{"key":"S0007114521000581_ref7","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyq267"},{"key":"S0007114521000581_ref34","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.111.016212"},{"key":"S0007114521000581_ref33","unstructured":"33. Institute of Medicine (US) and National Research Council (US) Committee to Reexamine IOM Pregnancy Weight Guidelines (2009) Weight gain during pregnancy: Reexamining the guidelines [Internet]. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK32813\/ (accessed August 2019)."},{"key":"S0007114521000581_ref43","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.115.123083"},{"key":"S0007114521000581_ref41","first-page":"801","article-title":"Physiological changes of pregnancy and monitoring","volume":"22","author":"Carlin","year":"2008","journal-title":"Crit Care Obstet"},{"key":"S0007114521000581_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.2004.tb00236.x"},{"key":"S0007114521000581_ref24","unstructured":"24. Perinatal Services BC (2018) British Columbia Perinatal Data Registry. Years Provided: 2015 to 2016. Resource Type: Data Extract. 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Perinatal Services BC (2020) Obstetric guideline: Prenatal screening for Down Syndrome, trisomy 18 and open neural tube defects [Internet]. http:\/\/www.perinatalservicesbc.ca\/Documents\/Guidelines-Standards\/Maternal\/PrenatalScreeningGuideline.pdf (accessed July 2020)."},{"key":"S0007114521000581_ref29","first-page":"1","article-title":"The World Health Organization fetal growth charts: a multinational longitudinal study of ultrasound biometric measurements and estimated fetal weight","volume":"14","author":"Kiserud","year":"2017","journal-title":"PLoS Med"},{"key":"S0007114521000581_ref15","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.226845"},{"key":"S0007114521000581_ref35","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-8101"},{"key":"S0007114521000581_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/S1701-2163(16)32758-X"},{"key":"S0007114521000581_ref23","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy201"},{"key":"S0007114521000581_ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60136-1"},{"key":"S0007114521000581_ref18","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.26947B"},{"key":"S0007114521000581_ref14","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.8.1863"},{"key":"S0007114521000581_ref30","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-19425-7"},{"key":"S0007114521000581_ref44","doi-asserted-by":"publisher","DOI":"10.1111\/mcn.12038"},{"key":"S0007114521000581_ref28","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2011-3846"},{"key":"S0007114521000581_ref45","doi-asserted-by":"publisher","DOI":"10.3945\/jn.115.211300"},{"key":"S0007114521000581_ref22","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.054619"},{"key":"S0007114521000581_ref17","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114517002331"},{"key":"S0007114521000581_ref4","first-page":"212","article-title":"Associations of maternal vitamin B12 concentration in pregnancy with the risks of preterm birth and low birth weight : a systematic review and meta-analysis of individual participant data","volume":"185","author":"Rogne","year":"2017","journal-title":"Am J Epidemiol"},{"key":"S0007114521000581_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.08.040"},{"key":"S0007114521000581_ref27","doi-asserted-by":"publisher","DOI":"10.1542\/peds.108.2.e35"},{"key":"S0007114521000581_ref1","doi-asserted-by":"publisher","DOI":"10.3945\/an.115.008201"},{"key":"S0007114521000581_ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2008.00031.x"},{"key":"S0007114521000581_ref3","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.112.056382"},{"key":"S0007114521000581_ref11","doi-asserted-by":"publisher","DOI":"10.4238\/gmr15048890"},{"key":"S0007114521000581_ref25","doi-asserted-by":"publisher","DOI":"10.1001\/jama.294.22.2879"},{"key":"S0007114521000581_ref42","doi-asserted-by":"publisher","DOI":"10.3324\/haematol.11636"},{"key":"S0007114521000581_ref16","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.113.060269"},{"key":"S0007114521000581_ref20","unstructured":"20. Perinatal Services BC (2017) Perinatal health report: Deliveries in British Columbia 2015\/16. Vancouver, BC [Internet]. http:\/\/www.perinatalservicesbc.ca\/Documents\/Data-Surveillance\/Reports\/PHR\/2015_16\/PHR_BC_2015_16.pdf (accessed August 2018)."},{"key":"S0007114521000581_ref6","doi-asserted-by":"publisher","DOI":"10.3109\/14767058.2016.1154525"},{"key":"S0007114521000581_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(77)90015-9"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114521000581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,15]],"date-time":"2023-05-15T02:27:15Z","timestamp":1684117635000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114521000581\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,19]]},"references-count":45,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12,28]]}},"alternative-id":["S0007114521000581"],"URL":"https:\/\/doi.org\/10.1017\/s0007114521000581","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,19]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. 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