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The aim of this study was to gain insight into how the hypothalamus regulates energy homoeostasis in Tibetan sheep. We compared Tibetan and Small-tailed Han sheep (\n                    <jats:italic>n<\/jats:italic>\n                    24 of each breed), which were each allocated randomly into four groups and offered one of four diets that differed in digestible energy densities: 8\u00b721, 9\u00b733, 10\u00b745 and 11\u00b757 MJ\/kg DM. Sheep were weighed every 2 weeks, and it was assumed that the change in body weight (BW) reflected the change in energy balance. The arcuate nucleus of the hypothalamus in Tibetan sheep had greater protein expressions of neuropeptide Y (NPY) and agouti-related peptide (AgRP) when in negative energy balance, but lesser protein expressions of proopiomelanocortin (POMC) and cocaine and amphetamine-regulated transcript (CART) when in positive energy balance than Small-tailed Han sheep. As a result, Tibetan sheep had a lesser BW loss when in negative energy balance and stored more energy and gained more BW when in positive energy balance than Small-tailed Han sheep with the same dietary intake. Moreover, in the hypothalamic adenosine monophosphate-activated protein kinase (AMPK) regulation pathway, Tibetan sheep had greater adenosine monophosphate-activated protein kinase-\n                    <jats:italic>\u03b1<\/jats:italic>\n                    2 protein expression than Small-tailed Han sheep, which supported the premise of a better ability to regulate energy homoeostasis and better growth performance. These differences in the hypothalamic NPY\/AgRP, POMC\/CART and AMPK pathways between breeds conferred an advantage to the Tibetan over Small-tailed Han sheep to cope with low energy intake on the harsh QTP.\n                  <\/jats:p>","DOI":"10.1017\/s0007114521001902","type":"journal-article","created":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T07:17:18Z","timestamp":1622791038000},"page":"1132-1142","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Hypothalamic regulation of energy homoeostasis when consuming diets of different energy concentrations: comparison between Tibetan and Small-tailed Han sheep"],"prefix":"10.1017","volume":"127","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1759-9366","authenticated-orcid":false,"given":"Xiaoping","family":"Jing","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yamin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Degen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenji","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingpeng","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luming","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhuan","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruijun","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,6,4]]},"reference":[{"key":"S0007114521001902_ref20","doi-asserted-by":"publisher","DOI":"10.1530\/REP-12-0507"},{"key":"S0007114521001902_ref38","doi-asserted-by":"publisher","DOI":"10.3168\/jds.S0022-0302(07)71636-3"},{"key":"S0007114521001902_ref6","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/1082","article-title":"Coexpression 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