{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T09:00:25Z","timestamp":1789030825533,"version":"build-2803163510"},"reference-count":45,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T00:00:00Z","timestamp":1627603200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2022,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Hyperemesis gravidarum (HG), severe nausea and vomiting in pregnancy, can lead to vitamin deficiencies. Little is known about HG-related vitamin K deficiency. We aimed to summarise available evidence on the occurrence of HG-related vitamin K deficiency and corresponding maternal and neonatal complications. A systematic review was conducted, searching Medline and EMBASE from inception to 12 November 2020. We identified 1564 articles, of which we included fifteen in this study: fourteen case reports (<jats:italic>n<\/jats:italic>21 women) and one retrospective cohort study (<jats:italic>n<\/jats:italic>109 women). Nine out of twenty-one women reported in case reports had a prolonged prothrombin time (PT). The cohort study measured PT in 39\/109 women with HG, of whom 10\/39 women (26 %) had prolonged PT. In total, 30\u201350 % women received vitamin K supplementation after vitamin K deficiency had been diagnosed. Four case reports (<jats:italic>n<\/jats:italic>4 women) reported corresponding maternal complications, all consisting of coagulopathy-related haemorrhage. Nine case reports (<jats:italic>n<\/jats:italic>16 neonates) reported corresponding neonatal complications including intracranial haemorrhage (<jats:italic>n<\/jats:italic>2 neonates) and embryopathy (<jats:italic>n<\/jats:italic>14 neonates), which consisted of Binder phenotype (<jats:italic>n<\/jats:italic>14 neonates), chondrodysplasia punctata (<jats:italic>n<\/jats:italic>9 neonates) and grey matter heterotopia (<jats:italic>n<\/jats:italic>3 neonates). In conclusion, vitamin K deficiency and related complications occur among women with HG. In our systematic review, we were unable to assess the incidence rate.<\/jats:p>","DOI":"10.1017\/s0007114521002865","type":"journal-article","created":{"date-parts":[[2021,7,30]],"date-time":"2021-07-30T07:40:59Z","timestamp":1627630859000},"page":"30-42","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":23,"title":["Hyperemesis gravidarum and vitamin K deficiency: a systematic review"],"prefix":"10.1017","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5308-5293","authenticated-orcid":false,"given":"Kelly","family":"Nijsten","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lo\u00efs","family":"van der Minnen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanke M.G.","family":"Wiegers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marjette H.","family":"Koot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saskia","family":"Middeldorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa J.","family":"Roseboom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris J.","family":"Grooten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca C.","family":"Painter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2021,7,30]]},"reference":[{"key":"S0007114521002865_ref22","unstructured":"22. 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Green-top Guideline No. 69. https:\/\/www.rcog.org.uk\/en\/guidelines-research-services\/guidelines\/gtg69\/ (accessed on July 2020)"},{"key":"S0007114521002865_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.01.015"},{"key":"S0007114521002865_ref1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1003896"},{"key":"S0007114521002865_ref8","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19971017)72:2<129::AID-AJMG2>3.0.CO;2-Q"},{"key":"S0007114521002865_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.soard.2019.05.031"},{"key":"S0007114521002865_ref5","doi-asserted-by":"publisher","DOI":"10.3945\/an.113.003855"},{"key":"S0007114521002865_ref19","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-041254"},{"key":"S0007114521002865_ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1992.tb05901.x"},{"key":"S0007114521002865_ref42","doi-asserted-by":"publisher","DOI":"10.1111\/j.1834-7819.1994.tb01379.x"},{"key":"S0007114521002865_ref20","doi-asserted-by":"publisher","DOI":"10.3163\/1536-5050.104.3.014"},{"key":"S0007114521002865_ref6","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1160\/TH08-03-0147","article-title":"Metabolism and cell biology of vitamin K","volume":"100","author":"Shearer","year":"2008","journal-title":"Thromb Haemost"},{"key":"S0007114521002865_ref24","first-page":"5384943","article-title":"Intraperitoneal hemorrhage in a pregnant woman with hyperemesis gravidarum: vitamin K deficiency as a possible cause","volume":"2016","author":"Baba","year":"2016","journal-title":"Case Rep Obstet Gynecol"},{"key":"S0007114521002865_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.04.014"},{"key":"S0007114521002865_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.03.006"},{"key":"S0007114521002865_ref23","doi-asserted-by":"publisher","DOI":"10.1097\/MCD.0b013e328335c14a"},{"key":"S0007114521002865_ref16","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.55.11.1603"},{"key":"S0007114521002865_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.lpm.2014.04.028"},{"key":"S0007114521002865_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31573"},{"key":"S0007114521002865_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2009.05.016"},{"key":"S0007114521002865_ref32","first-page":"324173","article-title":"Vitamin K Deficiency Embryopathy from Hyperemesis Gravidarum","volume":"2015","author":"Lane","year":"2015","journal-title":"Case Rep Obstet Gynecol"},{"key":"S0007114521002865_ref9","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.blre.2008.06.001","article-title":"Vitamin K deficiency bleeding (VKDB) in early infancy","volume":"23","author":"Shearer","year":"2009","journal-title":"Blood Rev"},{"key":"S0007114521002865_ref18","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(95)90501-4"},{"key":"S0007114521002865_ref44","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.04.022"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114521002865","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T17:31:52Z","timestamp":1699291912000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114521002865\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,30]]},"references-count":45,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,7,14]]}},"alternative-id":["S0007114521002865"],"URL":"https:\/\/doi.org\/10.1017\/s0007114521002865","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,30]]},"assertion":[{"value":"\u00a9 The Author(s), 2021. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is unaltered and is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use or in order to create a derivative work.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}