{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:36:46Z","timestamp":1790429806864,"version":"4.1.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2022,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Patients with liver cancer or space-occupying cysts suffer from malnutrition due to compression of gastric and digestive structures, liver and cancer-mediated dysmetabolism, and impaired nutrient absorption. As proportion of these patients requires removal of lesions through hepatic resection, it is important to evaluate the effects of malnutrition on post-hepatectomy outcomes. In our study approach, 2011\u20132017 National Inpatient Sample was used to isolate in-hospital hepatectomy cases, which were stratified using malnutrition (composite of malnutrition, sarcopenia and weight loss\/cachexia). The malnutrition-absent controls were matched to cases using nearest neighbour propensity score matching method and compared with the following endpoints: mortality, length of stay, hospitalisation costs and postoperative complications. There were 2531 patients in total who underwent hepatectomy with matched number of controls from the database; following the match, malnutrition cohort (compared with controls) was more likely to experience in-hospital death (6\u00b760 % <jats:italic>v<\/jats:italic>. 5\u00b725 % <jats:italic>P<\/jats:italic> &lt; 0\u00b7049, OR 1\u00b727, 95 % CI 1\u00b701, 1\u00b761) and was more likely to have higher length of stay (18\u00b710 d <jats:italic>v<\/jats:italic>. 9\u00b732 d, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001) and hospitalisation costs ($278\u00a0780 <jats:italic>v<\/jats:italic>. $150\u00a0812, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001). In terms of postoperative complications, malnutrition cohort was more likely to experience bleeding (6\u00b752 % <jats:italic>v<\/jats:italic>. 3\u00b787 %, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001, OR 1\u00b773, 95 % CI 1\u00b734, 2\u00b724), infection (6\u00b764 % <jats:italic>v<\/jats:italic>. 2\u00b749 %, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001, OR 2\u00b779, 95 % CI 2\u00b707, 3\u00b774), wound complications (4\u00b75 % <jats:italic>v<\/jats:italic>. 1\u00b738 %, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001, OR 3\u00b736, 95 % CI 2\u00b729, 4\u00b793) and respiratory failure (9\u00b740 % <jats:italic>v<\/jats:italic>. 4\u00b711 %, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001, OR 2\u00b742, 95 % CI 1\u00b791, 3\u00b707). In multivariate analysis, malnutrition was associated with higher mortality (<jats:italic>P<\/jats:italic> &lt; 0\u00b7028, adjusted OR 1\u00b73, 95 % CI 1\u00b703, 1\u00b765). Thus, we conclude that malnutrition is a risk factor of postoperative mortality in patients undergoing hepatectomy.<\/jats:p>","DOI":"10.1017\/s0007114521003809","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T08:02:44Z","timestamp":1632384164000},"page":"675-683","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":10,"title":["Malnutrition as a risk factor of adverse postoperative outcomes in patients undergoing hepatic resection: analysis of US hospitals"],"prefix":"10.1017","volume":"128","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7129-7532","authenticated-orcid":false,"given":"David Uihwan","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory 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