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One of the most significant complications that develops in patients with NEC is severe lung injury. We have previously shown that the administration of a nutritional formula that is enriched in pre-digested Triacylglyceride that do not require lipase action can significantly reduce the severity of NEC in a mouse model. We now hypothesise that this \u2018pre-digested fat (PDF) system\u2019 may reduce NEC-associated lung injury. In support of this hypothesis, we now show that rearing newborn mice on a nutritional formula based on the \u2018PDF system\u2019 promotes lung development, as evidenced by increased tight junctions and surfactant protein expression. Mice that were administered this \u2018PDF system\u2019 were significantly less vulnerable to the development of NEC-induced lung inflammation, and the administration of the \u2018PDF system\u2019 conferred lung protection. In seeking to define the mechanisms involved, the administration of the \u2018PDF system\u2019 significantly enhanced lung maturation and reduced the production of reactive oxygen species (ROS). These findings suggest that the PDF system protects the development of NEC-induced lung injury through effects on lung maturation and reduced ROS in the lung and also increases lung maturation in non-NEC mice.<\/jats:p>","DOI":"10.1017\/s0007114521004104","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T09:41:03Z","timestamp":1633945263000},"page":"1050-1063","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":16,"title":["The administration of a pre-digested fat-enriched formula prevents necrotising enterocolitis-induced lung injury in mice"],"prefix":"10.1017","volume":"128","author":[{"given":"Chhinder P.","family":"Sodhi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2672-386X","authenticated-orcid":false,"given":"Andres J.","family":"Gonzalez 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