{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:49:07Z","timestamp":1788965347938,"version":"build-2803163510"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2022,11,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We aimed to investigate the relationship between the neutrophil to lymphocyte ratio (NLR) and nutritional parameters in chronic kidney disease (CKD) patients. In this cross-sectional study, 187 non-dialysis CKD patients were enrolled. Daily dietary energy intake (DEI) and daily dietary protein intake (DPI) were assessed by 3-d dietary records. Protein-energy wasting (PEW) was defined as Subjective Global Assessment (SGA) class B and C. Spearman correlation analysis, logistic regression analysis and receiver operating characteristic (ROC) curve analysis were performed. The median NLR was 2\u00b751 (1\u00b783, 3\u00b783). Patients with CKD stage 5 had the highest NLR level. A total of 19\u00b73 % (<jats:italic>n<\/jats:italic> 36) of patients suffered from PEW. The NLR was positively correlated with SGA and serum P, and the NLR was negatively correlated with BMI, waist and hip circumference, triceps skinfold thickness, mid-arm muscle circumference, DPI and Hb. Multivariate logistic regression analysis adjusted for DPI, DEI, serum creatinine, blood urea nitrogen, uric acid and Hb showed that a high NLR was an independent risk factor for PEW (OR = 1\u00b7393, 95 % CI 1\u00b7078, 1\u00b7800, <jats:italic>P<\/jats:italic> = 0\u00b7011). ROC analysis showed that an NLR \u2265 2\u00b762 had the ability to identify PEW among CKD patients, with a sensitivity of 77\u00b78 %, a specificity of 62\u00b73 % and an AUC of 0\u00b771 (95 % CI 0\u00b763, 0\u00b781, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001). The NLR was closely associated with nutritional status. NLR may be an indicator of PEW in CKD patients.<\/jats:p>","DOI":"10.1017\/s000711452100516x","type":"journal-article","created":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T05:21:56Z","timestamp":1643347316000},"page":"1990-1996","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":15,"title":["A high neutrophil to lymphocyte ratio is associated with poor nutritional status in chronic kidney disease 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