{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T21:54:21Z","timestamp":1792274061640,"version":"4.4.0"},"reference-count":61,"publisher":"Cambridge University Press (CUP)","issue":"12","license":[{"start":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T00:00:00Z","timestamp":1646956800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2022,12,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Meal timing is a key factor in synchronising the circadian clock in peripheral tissues. Circadian disorders are associated with the metabolic syndrome. Previously, we demonstrated that a skipping breakfast regimen (SBR) with a high-fat diet increased body weight gain in rats. In this study, we investigated whether SBR with a normal diet led to abnormal lipid metabolism and muscle metabolism in mice. Male C57BL\/6 mice were fed during zeitgeber time (ZT) 12\u201324 in the control group and ZT 16\u201324 in the SBR group for 2 weeks. SBR mice showed increased body weight gain and perirenal adipose tissue weight. The plantar muscle weight was decreased in the SBR group compared with that in the control group. Furthermore, SBR delayed the circadian oscillations in clock gene expression in peripheral tissues, such as the liver, adipose tissue and muscle, as well as the oscillations in the expression of lipid metabolism-related genes in the liver and adipose tissue. These results suggest that skipping breakfast over a long period of time is associated with a risk of obesity, the metabolic syndrome and muscle loss, such as sarcopenia.<\/jats:p>","DOI":"10.1017\/s0007114522000356","type":"journal-article","created":{"date-parts":[[2022,3,11]],"date-time":"2022-03-11T04:34:47Z","timestamp":1646973287000},"page":"2308-2319","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":17,"title":["Skipping breakfast regimen induces an increase in body weight and a decrease in muscle weight with a shifted circadian rhythm in peripheral tissues of mice"],"prefix":"10.1017","volume":"128","author":[{"given":"Kohei","family":"Kiriyama","sequence":"first","affiliation":[{"name":"Nagoya University"},{"name":"Institute for Health Science, MIKI Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daeun","family":"Kim","sequence":"additional","affiliation":[{"name":"Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shumin","family":"Sun","sequence":"additional","affiliation":[{"name":"Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotaka","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Institute for Health Science, MIKI Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9129-9076","authenticated-orcid":false,"given":"Hiroaki","family":"Oda","sequence":"additional","affiliation":[{"name":"Nagoya University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,3,11]]},"reference":[{"key":"S0007114522000356_ref45","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00759.2001"},{"key":"S0007114522000356_ref29","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.2039"},{"key":"S0007114522000356_ref35","doi-asserted-by":"publisher","DOI":"10.1267\/ahc.10031"},{"key":"S0007114522000356_ref46","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.10.005"},{"key":"S0007114522000356_ref9","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.1000181"},{"key":"S0007114522000356_ref24","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454-2156.IntJSciRep20170354"},{"key":"S0007114522000356_ref33","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041150"},{"key":"S0007114522000356_ref30","doi-asserted-by":"publisher","DOI":"10.1177\/0748730410379711"},{"key":"S0007114522000356_ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.16.8819"},{"key":"S0007114522000356_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.jand.2014.08.022"},{"key":"S0007114522000356_ref17","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/253581"},{"key":"S0007114522000356_ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2443.2004.00769.x"},{"key":"S0007114522000356_ref42","doi-asserted-by":"publisher","DOI":"10.1038\/srep00439"},{"key":"S0007114522000356_ref32","doi-asserted-by":"publisher","DOI":"10.4161\/cc.23670"},{"key":"S0007114522000356_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.09.006"},{"key":"S0007114522000356_ref47","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.07.070187.001105"},{"key":"S0007114522000356_ref25","first-page":"249","article-title":"Effect of temperature and body size on the metabolic rate of the Egyptian house mice Mus Musculus and the roof rat Rattus Rattus","volume":"4","author":"Hussein","year":"1991","journal-title":"Med J Islamic World Acad Sci"},{"key":"S0007114522000356_ref61","doi-asserted-by":"publisher","DOI":"10.1139\/apnm-2017-0706"},{"key":"S0007114522000356_ref52","first-page":"336","article-title":"Clock regulation of dietary lipid absorption","volume":"15","author":"Hussain","year":"2012","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"S0007114522000356_ref22","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0206669"},{"key":"S0007114522000356_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(87)90021-2"},{"key":"S0007114522000356_ref1","doi-asserted-by":"publisher","DOI":"10.1111\/jdi.12075"},{"key":"S0007114522000356_ref54","first-page":"29","article-title":"Muscle insulin sensitivity and glucose metabolism are controlled by the intrinsic muscle clock","volume":"23","author":"Dyar","year":"2013","journal-title":"Mol Metab"},{"key":"S0007114522000356_ref51","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9100968"},{"key":"S0007114522000356_ref31","doi-asserted-by":"publisher","DOI":"10.1080\/07420520701534673"},{"key":"S0007114522000356_ref37","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.2001.280.2.E238"},{"key":"S0007114522000356_ref10","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.a2002"},{"key":"S0007114522000356_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/87.6.1914"},{"key":"S0007114522000356_ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-09289-9"},{"key":"S0007114522000356_ref49","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1114410109"},{"key":"S0007114522000356_ref55","first-page":"1","article-title":"The role of circadian rhythms in muscular and osseous physiology and their regulation by nutrition and exercise","volume":"14","author":"Aoyama","year":"2017","journal-title":"Front Neurosci"},{"key":"S0007114522000356_ref44","doi-asserted-by":"publisher","DOI":"10.1177\/0748730404269169"},{"key":"S0007114522000356_ref56","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1014523107"},{"key":"S0007114522000356_ref6","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030308"},{"key":"S0007114522000356_ref34","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0052-18.2018"},{"key":"S0007114522000356_ref50","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1449"},{"key":"S0007114522000356_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2011.06.005"},{"key":"S0007114522000356_ref60","first-page":"904","article-title":"Effects of fasting and refeeding on expression of MAFbx and MuRF1 in chick skeletal muscle","volume":"10","author":"Qinghe","year":"2011","journal-title":"Sci China Life Sci"},{"key":"S0007114522000356_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(90)90086-J"},{"key":"S0007114522000356_ref3","first-page":"7","article-title":"The underlying mechanisms for development of hypertension in the metabolic syndrome","volume":"17","author":"Yanai","year":"2008","journal-title":"Nutr J"},{"key":"S0007114522000356_ref36","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0037890"},{"key":"S0007114522000356_ref53","doi-asserted-by":"publisher","DOI":"10.1126\/science.1089287"},{"key":"S0007114522000356_ref11","doi-asserted-by":"publisher","DOI":"10.2185\/jrm.2887"},{"key":"S0007114522000356_ref48","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.111.042259"},{"key":"S0007114522000356_ref20","first-page":"30","article-title":"Skipping breakfast and the risk of cardiovascular disease and death: a systematic review of prospective cohort studies in primary prevention settings","volume":"22","author":"Ofori-Asenso","year":"2019","journal-title":"J Cardiovasc Dev Dis"},{"key":"S0007114522000356_ref27","doi-asserted-by":"publisher","DOI":"10.1080\/07420528.2019.1592185"},{"key":"S0007114522000356_ref41","doi-asserted-by":"publisher","DOI":"10.1126\/science.291.5503.490"},{"key":"S0007114522000356_ref19","doi-asserted-by":"publisher","DOI":"10.1017\/S1368980015000257"},{"key":"S0007114522000356_ref13","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-7-32"},{"key":"S0007114522000356_ref57","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-14596-2"},{"key":"S0007114522000356_ref18","first-page":"55","article-title":"Skipping breakfast and risk of mortality from cancer, circulatory diseases and all causes: findings from the Japan collaborative cohort study","volume":"59","author":"Yokoyama","year":"2016","journal-title":"Yonago Acta Med"},{"key":"S0007114522000356_ref59","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-012-9751-7"},{"key":"S0007114522000356_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.015"},{"key":"S0007114522000356_ref40","doi-asserted-by":"publisher","DOI":"10.2337\/db12-1765"},{"key":"S0007114522000356_ref58","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48161-w"},{"key":"S0007114522000356_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2019.01.016"},{"key":"S0007114522000356_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.04.019"},{"key":"S0007114522000356_ref38","doi-asserted-by":"publisher","DOI":"10.7600\/jpfsm.2.351"},{"key":"S0007114522000356_ref4","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1772"},{"key":"S0007114522000356_ref23","first-page":"488","article-title":"Effects of the physical form of the diet on food intake, growth, and body composition changes in mice","volume":"50","author":"Yan","year":"2011","journal-title":"J Am Assoc Lab Anim Sci"},{"key":"S0007114522000356_ref15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.109.199034"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114522000356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T09:18:32Z","timestamp":1783070312000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114522000356\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,11]]},"references-count":61,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12,28]]}},"alternative-id":["S0007114522000356"],"URL":"https:\/\/doi.org\/10.1017\/s0007114522000356","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,11]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}