{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T02:45:54Z","timestamp":1790649954492,"version":"4.1.0"},"reference-count":51,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2023,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Iodine, through the thyroid hormones, is required for the development of the auditory cortex and cochlea (the sensory organ for hearing). Deafness is a well-documented feature of endemic cretinism resulting from severe iodine deficiency. However, the range of effects of suboptimal iodine intake during auditory development on the hearing ability of children is less clear. We therefore aimed to systematically review the evidence for the association between iodine exposure (i.e. intake\/status\/supplementation) during development (i.e. pregnancy and\/or childhood) and hearing outcomes in children. We searched PubMed and Embase and identified 330 studies, of which thirteen were included in this review. Only three of the thirteen studies were of low risk of bias or of good quality, this therefore limited our ability to draw firm conclusions. Nine of the studies (69 %) were in children (one RCT, two non-RCT interventions and six cross-sectional studies) and four (31 %) were in pregnant women (one RCT, one cohort study and two case reports). The RCT of iodine supplementation in mildly iodine-deficient pregnant women found no effect on offspring hearing thresholds. However, hearing was a secondary outcome of the trial and not all women were from an iodine-deficient area. Iodine supplementation of severely iodine-deficient children (in both non-RCT interventions) resulted in improved hearing thresholds. Five of six cross-sectional studies (83 %) found that higher iodine status in children was associated with better hearing. The current evidence base for the association between iodine status and hearing outcomes is limited and further good-quality research on this topic is needed.<\/jats:p>","DOI":"10.1017\/s0007114522001441","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T07:36:11Z","timestamp":1652168171000},"page":"795-812","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Iodine status during child development and hearing ability: a systematic review"],"prefix":"10.1017","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4692-4191","authenticated-orcid":false,"given":"Mariana","family":"Dineva","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muqiu","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Blaskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5391-9932","authenticated-orcid":false,"given":"Sarah C.","family":"Bath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"S0007114522001441_ref4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60436-5"},{"key":"S0007114522001441_ref35","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S0140-6736(85)90460-X","article-title":"Improvement in hearing among otherwise normal schoolchildren in iodine-deficient areas of Guizhou, China, following use of iodized salt","volume":"326","author":"Wang","year":"1985","journal-title":"Lancet"},{"key":"S0007114522001441_ref43","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2013.251"},{"key":"S0007114522001441_ref9","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kws333"},{"key":"S0007114522001441_ref22","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"S0007114522001441_ref38","volume-title":"Institute of Medicine of the National Academies Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium and Zinc","year":"2001"},{"key":"S0007114522001441_ref49","doi-asserted-by":"publisher","DOI":"10.1136\/bmjpo-2018-000389"},{"key":"S0007114522001441_ref27","doi-asserted-by":"publisher","DOI":"10.1530\/acta.0.0780705"},{"key":"S0007114522001441_ref13","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-22553-w"},{"key":"S0007114522001441_ref18","unstructured":"18. WHO (2021) World Report on Hearing. Geneva: WHO; https:\/\/www.who.int\/teams\/noncommunicable-diseases\/sensory-functions-disability-and-rehabilitation\/highlighting-priorities-for-ear-and-hearing-care (accessed July 2021)."},{"key":"S0007114522001441_ref30","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2000.10.991"},{"key":"S0007114522001441_ref28","first-page":"54","article-title":"Relationship between urinary iodine concentration and hearing capacity in children","volume":"48","author":"Valeix","year":"1994","journal-title":"Eur J Clin Nutr"},{"key":"S0007114522001441_ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2009.08.014"},{"key":"S0007114522001441_ref23","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"S0007114522001441_ref42","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.572984"},{"key":"S0007114522001441_ref39","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2012.00528.x"},{"key":"S0007114522001441_ref5","doi-asserted-by":"publisher","DOI":"10.3390\/nu10091270"},{"key":"S0007114522001441_ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-4249"},{"key":"S0007114522001441_ref10","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq424"},{"key":"S0007114522001441_ref25","unstructured":"25. Wells, GA , Shea, B , O\u2019Connell, D , et al. (2021) The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Non-Randomised Studies in Meta-Analyses. Ottawa: Ottawa Hospital Research Institute. http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp (accessed July 2021)."},{"key":"S0007114522001441_ref44","unstructured":"44. Iodine Global Network (2021) Global Scorecard of Iodine Nutrition in 2021 in the General Population Based on School-Age Children (SAC). 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