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To investigate the function of NMU on appetite regulation of Siberian sturgeon (<jats:italic>Acipenser baerii<\/jats:italic>), this study first cloned<jats:italic>nmu<\/jats:italic>cDNA sequence that encoded 154 amino acids including NMU-25 peptide. Besides, the results showed that<jats:italic>nmu<\/jats:italic>mRNA was widely distributed in various tissues especially in the hypothalamus and telencephalon. The results of nutritional status (pre-feeding and post-feeding, fasting and re-feeding) experiments showed that<jats:italic>nmu<\/jats:italic>mRNA expression was significantly decreased at 1 and 3 h after feeding in different brain regions. Similarly, after feeding, the expression of<jats:italic>nmu<\/jats:italic>significantly decreased in peripheral tissues. Moreover,<jats:italic>nmu<\/jats:italic>expression in the hypothalamus was significantly increased after fasting 1 d, but decreased after fasting 17 d, which was significantly reversed after re-feeding. However, other brain regions like telencephalon and peripheral tissues like oesophagus, intestinum valvula and liver have different change patterns. Further study showed that acute<jats:italic>i.c.v.<\/jats:italic>and<jats:italic>i.p.<\/jats:italic>injection of NMU and chronic<jats:italic>i.p.<\/jats:italic>injection of NMU significantly reduced the food intake in a dose-dependent mode. In addition, the expressions of several critical appetite factors (<jats:italic>nmu<\/jats:italic>,<jats:italic>aplein<\/jats:italic>,<jats:italic>cart<\/jats:italic>,<jats:italic>cck<\/jats:italic>,<jats:italic>ghrelin<\/jats:italic>,<jats:italic>npy<\/jats:italic>,<jats:italic>nucb2<\/jats:italic>,<jats:italic>pyy<\/jats:italic>and<jats:italic>ucn3<\/jats:italic>) were significantly affected by acute NMU-25 administration in the hypothalamus, intestinum valvula and liver. These results indicate that NMU-25 has the anorexigenic function on food intake by affecting different appetite factors in Siberian sturgeon, which provides a foundation for further exploring the appetite regulation networks in fish.<\/jats:p>","DOI":"10.1017\/s0007114522001696","type":"journal-article","created":{"date-parts":[[2022,6,6]],"date-time":"2022-06-06T04:55:41Z","timestamp":1654491341000},"page":"904-918","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Neuromedin U regulates food intake of Siberian sturgeon through the modulation of central and peripheral appetite factors"],"prefix":"10.1017","volume":"129","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8777-0168","authenticated-orcid":false,"given":"Xin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhuang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ni","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuyao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youlian","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shupeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingzi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Defang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2022,6,6]]},"reference":[{"key":"S0007114522001696_ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.04.001"},{"key":"S0007114522001696_ref49","doi-asserted-by":"publisher","DOI":"10.1556\/018.68.2017.3.1"},{"key":"S0007114522001696_ref9","doi-asserted-by":"publisher","DOI":"10.1210\/en.2006-0866"},{"key":"S0007114522001696_ref39","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2018.06.008"},{"key":"S0007114522001696_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.05.007"},{"key":"S0007114522001696_ref31","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-1463"},{"key":"S0007114522001696_ref11","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.8.2514"},{"key":"S0007114522001696_ref59","first-page":"444","article-title":"Appetite-modifying actions of pro-neuromedin U-derived peptides","volume":"297","author":"Bechtold","year":"2009","journal-title":"Am J Physiol: Endocrinol Metab"},{"key":"S0007114522001696_ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.02079.x"},{"key":"S0007114522001696_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.07.108"},{"key":"S0007114522001696_ref33","volume-title":"The State of World Fisheries and Aquaculture","year":"2019"},{"key":"S0007114522001696_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.regpep.2005.01.007"},{"key":"S0007114522001696_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2017.09.011"},{"key":"S0007114522001696_ref37","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12646-3"},{"key":"S0007114522001696_ref6","doi-asserted-by":"publisher","DOI":"10.1101\/gad.11.5.593"},{"key":"S0007114522001696_ref24","doi-asserted-by":"publisher","DOI":"10.1530\/JME-15-0018"},{"key":"S0007114522001696_ref64","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3724\/issn1000-3207-2003-6-590-j","article-title":"Comparative study on activities of digestive enzyme in A. 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