{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:51:50Z","timestamp":1747173110346,"version":"3.40.5"},"reference-count":20,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2023,5,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amino acids are an essential part of parenteral nutrition. This study aimed to determine the serum profile of amino acids and their loss in urine in patients with long-term home parenteral nutrition (HPN) during 12 h of infusion in comparison with similar parameters in the remaining 12 h as well as in healthy participants. We enrolled forty-five patients with long-term HPN for 6\u201375 (median, 33) months. The indication for HPN was short bowel syndrome secondary to radical resection of the small intestine following complications of Crohn\u2019s disease. HPN was administered via two-chamber all-in-one bags prepared in a hospital pharmacy overnight for 12 h each day. The average dose of amino acids, carbohydrates and fats administered was 1\u00b75, 3\u00b74 and 0\u00b768 g\/kg per d, respectively, at an infusion rate of 0\u00b711, 0\u00b728 and 0\u00b706 g\/kg per h, respectively. The levels of essential amino acids in the serum of the patients were not significantly different from those in healthy individuals; however, of the non-essential amino acids, cystine and glutamine levels were lower and glycine and ornithine levels were higher in the patients (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Excretion of amino acids in the urine during 12 h of infusion at an infusion rate of 0\u00b711 g\/kg per h was 301 mg, while it was 104 mg during the remaining 12 h (<jats:italic>P<\/jats:italic> &lt; 0\u00b70001). Our patients on long-term HPN had a normal serum profile of essential amino acids. The total urinary excretion of amino acids during 12 h of infusion accounted for only 0\u00b734 % (0\u00b723\u20130\u00b746) of the administered dose.<\/jats:p>","DOI":"10.1017\/s0007114522002008","type":"journal-article","created":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T09:06:32Z","timestamp":1659344792000},"page":"1537-1542","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":2,"title":["Long-term home parenteral nutrition and profile of amino acids in serum and their loss in urine"],"prefix":"10.1017","volume":"129","author":[{"suffix":"Jr","given":"Milan","family":"Dastych","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michal","family":"\u0160enky\u0159\u00edk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alena","family":"Miku\u0161kov\u00e1","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7187-080X","authenticated-orcid":false,"given":"Milan","family":"Dastych","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2022,8,1]]},"reference":[{"key":"S0007114522002008_ref14","first-page":"493","article-title":"Tubular handling of amino acids after intravenous infusion of amino acids in healthy humans","volume":"7","author":"Tietze","year":"1992","journal-title":"Nefrol Dial Transplant"},{"key":"S0007114522002008_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2020.03.005"},{"key":"S0007114522002008_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0455-4"},{"key":"S0007114522002008_ref5","doi-asserted-by":"publisher","DOI":"10.1159\/000515057"},{"key":"S0007114522002008_ref16","doi-asserted-by":"publisher","DOI":"10.1172\/JCI102022"},{"key":"S0007114522002008_ref19","doi-asserted-by":"publisher","DOI":"10.1177\/0148607182006003204"},{"key":"S0007114522002008_ref2","doi-asserted-by":"publisher","DOI":"10.1097\/01.TP.0000126931.23349.15"},{"key":"S0007114522002008_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-005-0006-0"},{"key":"S0007114522002008_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.07.024"},{"key":"S0007114522002008_ref17","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/0022-3468(73)90423-5","article-title":"Amino acids utilization during total parenteral nutrition in the surgical neonate","volume":"8","author":"Da","year":"1973","journal-title":"J Pediatr Surg"},{"key":"S0007114522002008_ref4","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050466"},{"key":"S0007114522002008_ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(03)00042-6"},{"key":"S0007114522002008_ref13","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c130028"},{"key":"S0007114522002008_ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.02.013"},{"key":"S0007114522002008_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.01.020"},{"key":"S0007114522002008_ref3","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-014-0427-8"},{"key":"S0007114522002008_ref6","doi-asserted-by":"publisher","DOI":"10.1111\/apt.12209"},{"key":"S0007114522002008_ref18","first-page":"123","article-title":"Study of the elimination of amino acids in the urine during parenteral feeding with a complete food, trivemil (EB 51)","volume":"15","author":"Francois","year":"1974","journal-title":"Annales l\u02c7Anesthesiologie Francaise"},{"key":"S0007114522002008_ref12","doi-asserted-by":"publisher","DOI":"10.3390\/nu12030772"},{"key":"S0007114522002008_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2018.06.964"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114522002008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T10:52:01Z","timestamp":1682592721000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114522002008\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,1]]},"references-count":20,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,5,14]]}},"alternative-id":["S0007114522002008"],"URL":"https:\/\/doi.org\/10.1017\/s0007114522002008","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"type":"print","value":"0007-1145"},{"type":"electronic","value":"1475-2662"}],"subject":[],"published":{"date-parts":[[2022,8,1]]},"assertion":[{"value":"\u00a9 The Author(s), 2022. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}