{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T01:07:36Z","timestamp":1768439256052,"version":"3.49.0"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"10","license":[{"start":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T00:00:00Z","timestamp":1660867200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2023,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Vitamin D (VD) deficiency (serum 25 hydroxy vitamin D (25(OH)D) concentration of &lt; 20 ng\/ml), in endemic proportions, demands a supplementation strategy with optimal dosing regimens. A randomised parallel-group, active-controlled trial was conducted among apparently healthy, VD-deficient subjects, aged 18\u201360 years who received 600 \u03bcg\/d (Group A), 1000 \u03bcg\/d (Group B), 2000 \u03bcg\/d (Group C) and 60\u00a0000 \u03bcg\/month (Group D) of oral cholecalciferol. The intervention was carried in two phases (I and II) of 12 weeks each, with same dose, separated by a washout phase of 12 weeks. Serum 25(OH)D, intact parathyroid hormones (iPTH), Ca, phosphorous (PO4), alkaline phosphatase (ALP) and spot urine Ca\/Cr were measured at baseline, 12, 24 and 36 weeks following the intervention, and adverse events were recorded at each occurrence and at 12, 24 and 36 weeks. A statistically significant time\u2013group interaction was found in serum 25(OH)D concentration (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Serum 25(OH)D concentration increased significantly from baseline to 12 weeks (<jats:italic>P<\/jats:italic> &lt; 0\u00b705) in all the groups with no change at 24 weeks but further increase at 36 weeks (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). At the end of the study, Group C had maximum increment in serum 25(OH)D concentration, while as Groups C and D (95 %, and 90 %) had higher proportion of subjects VD sufficient than Groups A and B (65 % and 78 %) (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). No significant time\u2013dose interactions were observed in serum iPTH, Ca, PO4 and ALP or urine Ca\/Cr ratio. Three subjects (two in Group C and one in Group D) developed transient hypercalciuria. Supplementation with daily 2000 \u03bcg or monthly 60\u00a0000 \u03bcg of oral cholecalciferol among adults seems optimal and safe.<\/jats:p>","DOI":"10.1017\/s0007114522002641","type":"journal-article","created":{"date-parts":[[2022,8,19]],"date-time":"2022-08-19T09:02:00Z","timestamp":1660899720000},"page":"1732-1739","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Efficacy and safety of various oral regimens (three oral doses) and schedules (daily <i>v<\/i>. monthly) of cholecalciferol in North Indian adults with low vitamin D status: evidence from a randomised controlled trial"],"prefix":"10.1017","volume":"129","author":[{"given":"Mohd Ashraf","family":"Ganie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shivani","family":"Sidana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad 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