{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:27:48Z","timestamp":1792621668521,"version":"4.5.0"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T00:00:00Z","timestamp":1669334400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2023,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Observational studies suggest that 25-hydroxy vitamin D (25(OH)D) concentration is inversely associated with pain. However, findings from intervention trials are inconsistent. We assessed the effect of vitamin D supplementation on pain using data from a large, double-blind, population-based, placebo-controlled trial (the D-Health Trial). 21\u00a0315 participants (aged 60\u201384 years) were randomly assigned to a monthly dose of 60\u00a0000 IU vitamin D<jats:sub>3<\/jats:sub> or matching placebo. Pain was measured using the six-item Pain Impact Questionnaire (PIQ-6), administered 1, 2 and 5 years after enrolment. We used regression models (linear for continuous PIQ-6 score and log-binomial for binary categorisations of the score, namely \u2018some or more pain impact\u2019 and \u2018presence of any bodily pain\u2019) to estimate the effect of vitamin D on pain. We included 20\u00a0423 participants who completed \u22651 PIQ-6. In blood samples collected from 3943 randomly selected participants (\u223c800 per year), the mean (<jats:sc>sd<\/jats:sc>) 25(OH)D concentrations were 77 (<jats:sc>sd<\/jats:sc> 25) and 115 (<jats:sc>sd<\/jats:sc> 30) nmol\/l in the placebo and vitamin D groups, respectively. Most (76 %) participants were predicted to have 25(OH)D concentration &gt;50 nmol\/l at baseline. The mean PIQ-6 was similar in all surveys (\u223c50\u00b74). The adjusted mean difference in PIQ-6 score (vitamin D cf placebo) was 0\u00b702 (95 % CI (\u22120\u00b720, 0\u00b725)). The proportion of participants with some or more pain impact and with the presence of bodily pain was also similar between groups (both prevalence ratios 1\u00b701, 95 % CI (0\u00b799, 1\u00b703)). In conclusion, supplementation with 60\u00a0000 IU of vitamin D<jats:sub>3<\/jats:sub>\/month had negligible effect on bodily pain.<\/jats:p>","DOI":"10.1017\/s0007114522003567","type":"journal-article","created":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T08:27:11Z","timestamp":1669364831000},"page":"633-640","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["The effect of vitamin D supplementation on pain: an analysis of data from the D-Health randomised controlled trial"],"prefix":"10.1017","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2487-9254","authenticated-orcid":false,"given":"Aninda","family":"Rahman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Waterhouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Baxter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Briony Duarte","family":"Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald S. 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Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}