{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T06:10:59Z","timestamp":1759731059346,"version":"3.40.5"},"reference-count":50,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2023,10,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An abnormal Zn status has been suggested to play a role in the pathogenesis of type 2 diabetes. However, epidemiological studies of the relationship between plasma Zn concentrations and diabetes are sparse and inconclusive. We aimed to investigate the association between plasma Zn concentrations and glycaemic markers (fasting glucose, 2-h glucose and homeostatic model assessment of insulin resistance) in rural and urban Cameroon. We studied 596 healthy adults (63\u00b73 % women) aged 25\u201355 years in a population-based cross-sectional study. The mean plasma Zn concentration was 13\u00b77 \u00b1 2\u00b77 \u00b5mol\/L overall, with higher levels in men (14\u00b74 \u00b1 2\u00b79 \u00b5mol\/l) than in women (13\u00b72 \u00b1 2\u00b76 \u00b5mol\/l),<jats:italic>P<\/jats:italic>-value &lt; 0\u00b70001. There was an inverse relationship between tertiles of plasma Zn and 2-h glucose concentrations (<jats:italic>P<\/jats:italic>-value for linear trend = 0\u00b7002). The difference in 2-h glucose between those in the highest tertile of plasma Zn compared to the lowest was \u22120\u00b763 (95 % CI \u2212 1\u00b702, \u22120\u00b723) mmol\/l. This remained significant after adjusting for age, sex, smoking status, alcohol intake, education level, area of residence, adiposity and objectively measured physical activity \u22120\u00b743(\u20130\u00b782, \u22120\u00b704). Similar inverse associations were observed between plasma Zn concentrations and fasting glucose and homeostatic model assessment of insulin resistance when adjusted for socio-demographic and health-related behavioural characteristics. The current findings of an inverse association between plasma Zn concentrations and several markers of glucose homeostasis, together with growing evidence from intervention studies, suggest a role for Zn in glucose metabolism. If supported by further evidence, strategies to improve Zn status in populations may provide a cheap public health prevention approach for diabetes.<\/jats:p>","DOI":"10.1017\/s0007114523000223","type":"journal-article","created":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:51:51Z","timestamp":1674607911000},"page":"1220-1227","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["The association between plasma zinc concentrations and markers of glucose metabolism in adults in Cameroon"],"prefix":"10.1017","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6186-8944","authenticated-orcid":false,"given":"Camille M.","family":"Mba","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7380-9797","authenticated-orcid":false,"given":"Kerry S.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nita G.","family":"Forouhi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumiaki","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Assah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean Claude","family":"Mbanya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicholas J.","family":"Wareham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"S0007114523000223_ref38","first-page":"482","article-title":"Association between plasma metal levels and diabetes risk: a case-control study in China","volume":"30","author":"Li","year":"2017","journal-title":"BES"},{"key":"S0007114523000223_ref27","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"S0007114523000223_ref12","doi-asserted-by":"publisher","DOI":"10.2337\/dc08-1913"},{"key":"S0007114523000223_ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2017.02.010"},{"key":"S0007114523000223_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00618-8"},{"key":"S0007114523000223_ref28","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/nxy105"},{"key":"S0007114523000223_ref6","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.5.1378S"},{"key":"S0007114523000223_ref32","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85977-x"},{"key":"S0007114523000223_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2016.12.017"},{"key":"S0007114523000223_ref22","unstructured":"22. 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(2014) National Diet and Nutrition Survey. 160. https:\/\/www.food.gov.uk\/sites\/default\/files\/media\/document\/ndnsfullreport.pdf (accessed September 2021)."},{"key":"S0007114523000223_ref9","doi-asserted-by":"publisher","DOI":"10.1038\/srep10974"},{"key":"S0007114523000223_ref5","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/130.11.2838"},{"key":"S0007114523000223_ref24","doi-asserted-by":"publisher","DOI":"10.1249\/mss.0b013e3180616b27"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114523000223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T15:06:07Z","timestamp":1701788767000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114523000223\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,25]]},"references-count":50,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2023,10,14]]}},"alternative-id":["S0007114523000223"],"URL":"https:\/\/doi.org\/10.1017\/s0007114523000223","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"type":"print","value":"0007-1145"},{"type":"electronic","value":"1475-2662"}],"subject":[],"published":{"date-parts":[[2023,1,25]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. 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