{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:52:26Z","timestamp":1747173146103,"version":"3.40.5"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2023,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study evaluated the association between maternal magnesium intake (MMI) and childhood wheezing incidence in 3-year-old offspring. We hypothesised that higher MMI imparts anti-inflammatory and antioxidant effects that decrease childhood wheezing incidence in offspring. Data of 79\u00a0907 women (singleton pregnancy, \u2265 22 weeks) from the Japan Environment and Children\u2019s Study (enrolled between 2011 and 2014) were analysed. Participants were categorised into quintiles of MMI (&lt; 148\u00b700, 148\u00b700\u2013187\u00b799, 188\u00b700\u2013228\u00b799, 229\u00b700\u2013289\u00b799 and \u2265 290\u00b700 mg\/d), quintiles of adjusted MMI for daily energy intake (aMMI) (&lt; 0\u00b7107, 0\u00b7107\u20130\u00b7119, 0\u00b7120\u20130\u00b7132, 0\u00b7133\u20130\u00b7149 and \u2265 0\u00b7150 mg\/kcal) and MMI levels either below or above the ideal value (&lt; 310\u00b700 or \u2265 310\u00b700 mg\/d). Multivariable logistic regression analysis was performed to calculate OR for the incidence of childhood wheezing in offspring among participants in each MMI category, with the lowest MMI group considered the reference group. Maternal demographic, socio-economic, medical and other nutrient intake backgrounds were considered potential confounding factors. The adjusted OR (aOR) for childhood wheezing in the offspring of women with the highest MMI was 1\u00b709 (95 % CI, 1\u00b700, 1\u00b720), whereas that calculated based on aMMI categories and offspring of women with above-ideal MMI levels remained unchanged. The highest MMI was associated with slightly increased childhood wheezing incidence in the offspring. MMI during pregnancy had an insignificant clinical impact on this incidence; moreover, modifying MMI would not significantly improve childhood wheezing incidence in offspring. Therefore, further studies should clarify the association between other prenatal factors and childhood wheezing incidence in offspring.<\/jats:p>","DOI":"10.1017\/s0007114523000922","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T08:11:28Z","timestamp":1685088688000},"page":"1973-1981","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Maternal magnesium intake and childhood wheezing in offspring at 3 years of age: the Japan Environment and Children\u2019s 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