{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:30:19Z","timestamp":1788813019351,"version":"build-2803163510"},"reference-count":39,"publisher":"Cambridge University Press (CUP)","issue":"11","license":[{"start":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T00:00:00Z","timestamp":1683072000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2023,12,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:sc>D-<\/jats:sc>allulose, <jats:sc>D-<\/jats:sc>sorbose and <jats:sc>D-<\/jats:sc>tagatose are <jats:sc>D-<\/jats:sc>fructose isomers that are called rare sugars. These rare sugars have been studied intensively in terms of biological production and food application as well as physiological effects. There are limited papers with regard to the transporters mediating the intestinal absorption of these rare sugars. We examined whether these rare sugars are absorbed via sodium-dependent glucose cotransporter 1 (SGLT1) as well as via GLUT type 5 (GLUT5) using rats. High-fructose diet fed rats, which express more intestinal GLUT5, exhibited significantly higher peripheral concentrations, Cmax and AUC<jats:sub>0\u2013180 min<\/jats:sub> when D-allulose, D-sorbose and D-tagatose were orally administrated. KGA-2727, a selective SGLT1 inhibitor, did not affect the peripheral and portal vein concentrations and pharmacokinetic parameters of these rare sugars. The results suggest that D-allulose, D-sorbose and D-tagatose are likely transported via GLUT5 but not SGLT1 in rat small intestine.<\/jats:p>","DOI":"10.1017\/s0007114523001113","type":"journal-article","created":{"date-parts":[[2023,5,3]],"date-time":"2023-05-03T06:27:49Z","timestamp":1683095269000},"page":"1852-1858","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Intestinal absorption of <scp>D<\/scp>-fructose isomers, <scp>D<\/scp>-allulose, <scp>D<\/scp>-sorbose and <scp>D<\/scp>-tagatose, via glucose transporter type 5 (GLUT5) but not sodium-dependent glucose cotransporter 1 (SGLT1) in rats"],"prefix":"10.1017","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8496-7857","authenticated-orcid":false,"given":"Kunihiro","family":"Kishida","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuo","family":"Iida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiyasu","family":"Toyoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,5,3]]},"reference":[{"key":"S0007114523001113_ref32","doi-asserted-by":"publisher","DOI":"10.1096\/fj.15-272195"},{"key":"S0007114523001113_ref8","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02488-y"},{"key":"S0007114523001113_ref39","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1055\/s-0043-106050","article-title":"Natural products as lead compounds for Sodium Glucose Cotransporter (SGLT) inhibitors","volume":"83","author":"Blaschek","year":"2017","journal-title":"Planta Med"},{"key":"S0007114523001113_ref27","doi-asserted-by":"publisher","DOI":"10.4327\/jsnfs.63.17"},{"key":"S0007114523001113_ref34","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.48.77"},{"key":"S0007114523001113_ref7","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.12908"},{"key":"S0007114523001113_ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2016.01.030"},{"key":"S0007114523001113_ref21","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114521003172"},{"key":"S0007114523001113_ref22","first-page":"225","article-title":"Metabolic effects of D-psicose in rats: studies on faecal and urinary excretion and caecal fermentation","volume":"12","author":"Matsuo","year":"2003","journal-title":"Asia Pac J Clin Nutr"},{"key":"S0007114523001113_ref18","doi-asserted-by":"publisher","DOI":"10.1089\/109662002753723197"},{"key":"S0007114523001113_ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2621.2009.01909.x"},{"key":"S0007114523001113_ref17","doi-asserted-by":"publisher","DOI":"10.3177\/jnsv.60.297"},{"key":"S0007114523001113_ref25","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/73.1.105"},{"key":"S0007114523001113_ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.metop.2021.100112"},{"key":"S0007114523001113_ref31","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-nutr-082117-051707"},{"key":"S0007114523001113_ref14","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14358"},{"key":"S0007114523001113_ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2015.08.004"},{"key":"S0007114523001113_ref20","doi-asserted-by":"publisher","DOI":"10.3390\/nu14163350"},{"key":"S0007114523001113_ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-018-8916-6"},{"key":"S0007114523001113_ref26","first-page":"75","article-title":"Evaluation of absorption and fermentability of D-mannose, D-sorbose, and D-allose in humans","volume":"22","author":"Kitagawa","year":"2018","journal-title":"J Jpn Assoc for Dietary Fiber Res"},{"key":"S0007114523001113_ref28","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2018.11.003"},{"key":"S0007114523001113_ref3","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8718053"},{"key":"S0007114523001113_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nut.2017.06.007"},{"key":"S0007114523001113_ref30","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.112.193045"},{"key":"S0007114523001113_ref33","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2009.07.018"},{"key":"S0007114523001113_ref36","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(75)80828-3"},{"key":"S0007114523001113_ref35","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)70898-3"},{"key":"S0007114523001113_ref1","unstructured":"1. International Society of Rare Sugars (ISRS) (2002) Definition of Rare Sugars. https:\/\/www.isrs.kagawa-u.ac.jp\/definition.html (accessed January 2023)."},{"key":"S0007114523001113_ref23","first-page":"1955","article-title":"Intestinal absorption, organ distribution, and urinary excretion of the rare sugar D-psicose","volume":"8","author":"Tsukamoto","year":"2014","journal-title":"Drug Devel Ther"},{"key":"S0007114523001113_ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.09.147"},{"key":"S0007114523001113_ref24","doi-asserted-by":"publisher","DOI":"10.1006\/rtph.1998.1251"},{"key":"S0007114523001113_ref38","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00055.2009"},{"key":"S0007114523001113_ref4","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.70450"},{"key":"S0007114523001113_ref9","doi-asserted-by":"publisher","DOI":"10.1080\/10408398.2015.1126550"},{"key":"S0007114523001113_ref37","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(82)90372-1"},{"key":"S0007114523001113_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2017.01.004"},{"key":"S0007114523001113_ref12","doi-asserted-by":"publisher","DOI":"10.1002\/jsfa.8687"},{"key":"S0007114523001113_ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2014.09.009"},{"key":"S0007114523001113_ref5","first-page":"3422","article-title":"Combined treatment with D-allose, docetaxel and radiation inhibits the tumor growth in an in vivo model of head and neck cancer","volume":"15","author":"Hoshikawa","year":"2018","journal-title":"Oncol lett"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114523001113","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,7]],"date-time":"2023-11-07T13:18:31Z","timestamp":1699363111000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114523001113\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,3]]},"references-count":39,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,12,14]]}},"alternative-id":["S0007114523001113"],"URL":"https:\/\/doi.org\/10.1017\/s0007114523001113","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,3]]},"assertion":[{"value":"\u00a9 The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}