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Providing alternative terrestrial ingredients early in feeding influences the growth of rainbow trout (RT, <jats:italic>Oncorhynchus mykiss<\/jats:italic>). Thus, the present study aimed to assess the influence, <jats:italic>via<\/jats:italic> long-term feeding (from the first feeding to 8 months), of alternative plant ingredients (V diet for vegetable diet <jats:italic>v.<\/jats:italic> C diet for a control diet) in RT on the mechanism of fat sensing at the gustatory level. After the feeding trial, we studied the pathways of the fat-sensing mechanism in tongue tissue and the integrated response in the brain. To this end, we analysed the expression pattern of free fatty acid receptors (<jats:italic>ffar<\/jats:italic>) 1 and 2, markers of calcium-signalling pathways (phospholipase C<jats:italic>\u03b2<\/jats:italic>, Orai, Stim or Serca), the serotonin level (a key neurotransmitter in taste buds) and the expression pattern of appetite-regulating neuropeptides in the hypothalamus (central area of appetite regulation). The results revealed that the V diet modified the expression pattern of <jats:italic>ffar1<\/jats:italic> and paralogs of <jats:italic>ffar2<\/jats:italic> genes in tongue tissue, along with differential regulation of calcium-signalling pathways and a defect in serotonin level and brain turnover, without influencing neuropeptide expression. This study is the first to support that changes in feeding behaviour of RT fed a V diet could be due to the difference in nutrient sensing and a decrease in hedonic sensation. We revealed that RT have similar fat-detection mechanisms as mammals.<\/jats:p>","DOI":"10.1017\/s0007114523001599","type":"journal-article","created":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T05:32:08Z","timestamp":1689831128000},"page":"1-16","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":11,"title":["Long-term regulation of fat sensing in rainbow trout (<i>Oncorhynchus mykiss<\/i>) fed a vegetable diet from the first feeding: focus on free fatty acid receptors and their 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