{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:26:33Z","timestamp":1791296793254,"version":"4.1.0"},"reference-count":43,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2024,2,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Postmenopausal women have augmented pressure wave responses to low-intensity isometric handgrip exercise (IHG) due to an overactive metaboreflex (postexercise muscle ischaemia, PEMI), contributing to increased aortic systolic blood pressure (SBP). Menopause-associated endothelial dysfunction via arginine (ARG) and nitric oxide deficiency may contribute to exaggerated exercise SBP responses. L-Citrulline supplementation (CIT) is an ARG precursor that decreases SBP, pulse pressure (PP) and pressure wave responses to cold exposure in older adults. We investigated the effects of CIT on aortic SBP, PP, and pressure of forward (Pf) and backward (Pb) waves during IHG and PEMI in twenty-two postmenopausal women. Participants were randomised to CIT (10 g\/d) or placebo (PL) for 4 weeks. Aortic haemodynamics were assessed via applanation tonometry at rest, 2 min of IHG at 30 % of maximal strength, and 3 min of PEMI. Responses were analysed as change (\u0394) from rest to IHG and PEMI at 0 and 4 weeks. CIT attenuated \u0394SBP (\u22129 \u00b1 2 <jats:italic>v<\/jats:italic>. \u22121 \u00b1 1 mmHg, <jats:italic>P<\/jats:italic> = 0\u00b7006), \u0394PP (\u22125 \u00b1 2 <jats:italic>v<\/jats:italic>. 0 \u00b1 1 mmHg, <jats:italic>P<\/jats:italic> = 0\u00b703), \u0394Pf (\u22126 \u00b1 2 <jats:italic>v<\/jats:italic>. \u22121 \u00b1 1 mmHg, <jats:italic>P<\/jats:italic> = 0\u00b701) and \u0394Pb (\u22123 \u00b1 1 <jats:italic>v<\/jats:italic>. 0 \u00b1 1 mmHg, <jats:italic>P<\/jats:italic> = 0\u00b702) responses to PEMI <jats:italic>v<\/jats:italic>. PL. The \u0394PP during PEMI was correlated with \u0394Pf (<jats:italic>r<\/jats:italic> = 0\u00b7743, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001) and \u0394Pb (<jats:italic>r<\/jats:italic> = 0\u00b7724, <jats:italic>P<\/jats:italic> &lt; 0\u00b7001). Citrulline supplementation attenuates the increase in aortic pulsatile load induced by muscle metaboreflex activation via reductions in forward and backward pressure wave amplitudes in postmenopausal women.<\/jats:p>","DOI":"10.1017\/s000711452300199x","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T10:35:25Z","timestamp":1693823725000},"page":"474-481","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":8,"title":["L-Citrulline supplementation attenuates aortic pressure and pressure waves during metaboreflex activation in postmenopausal women"],"prefix":"10.1017","volume":"131","author":[{"given":"Katherine 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Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}