{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T06:46:41Z","timestamp":1770533201732,"version":"3.49.0"},"reference-count":28,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T00:00:00Z","timestamp":1696809600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2024,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Obesity is associated with low vitamin D status, and the optimal supplement and dosage of cholecalciferol (vitamin D<jats:sub>3<\/jats:sub>) or calcidiol (25OHD) for individuals with obesity have been debated. We aimed to determine the effect of high-dose vitamin D<jats:sub>3<\/jats:sub> supplementation on achieving adequate vitamin D levels among infertile men with normal weight <jats:italic>v<\/jats:italic>. obesity. Here, we present secondary end points from a single-centre, double-blinded, randomised clinical trial, comprising 307 infertile men randomised to active or placebo treatment for 150 days. Men in the active group initially received an oral bolus of 300\u00a0000 mg of vitamin D<jats:sub>3<\/jats:sub>, followed by daily supplementation with 1400 mg of vitamin D<jats:sub>3<\/jats:sub> and 500 mg of calcium. Baseline BMI was listed as a predefined subgroup. At baseline, serum 25OHD was significantly higher in men with normal weight (BMI &lt; 25 kg\/m<jats:sup>2<\/jats:sup>) compared with men with overweight (BMI 25\u201330 kg\/m<jats:sup>2<\/jats:sup>) and obesity (BMI &gt; 30 kg\/m<jats:sup>2<\/jats:sup>) (48 nmol\/l <jats:italic>v<\/jats:italic>. 45 nmol\/l and 39 nmol\/l, respectively; <jats:italic>P<\/jats:italic> = 0\u00b7024). After the intervention, men with normal weight, overweight and obesity treated with vitamin D<jats:sub>3<\/jats:sub> had a significantly higher serum 25OHD compared with corresponding placebo-treated men (BMI &lt; 25 kg\/m<jats:sup>2<\/jats:sup>: 92 nmol\/l <jats:italic>v<\/jats:italic>. 53 nmol\/l, BMI = 25\u201330 kg\/m<jats:sup>2<\/jats:sup>: 87 nmol\/l <jats:italic>v<\/jats:italic>. 49 nmol\/l and BMI &gt; 30 kg\/m<jats:sup>2<\/jats:sup>: 85 nmol\/l <jats:italic>v<\/jats:italic>. 48 nmol\/l; <jats:italic>P<\/jats:italic> &lt; 0\u00b7001 for all, respectively). In conclusion, we show that high-dose vitamin D<jats:sub>3<\/jats:sub> supplementation to infertile men with obesity and low vitamin D status is sufficient to achieve adequate serum 25OHD levels.<\/jats:p>","DOI":"10.1017\/s0007114523002222","type":"journal-article","created":{"date-parts":[[2023,10,9]],"date-time":"2023-10-09T10:54:14Z","timestamp":1696848854000},"page":"642-647","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["High-dose cholecalciferol supplementation to obese infertile men is sufficient to reach adequate vitamin D status"],"prefix":"10.1017","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2489-3216","authenticated-orcid":false,"given":"Rune","family":"Holt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads 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