{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T21:52:44Z","timestamp":1747173164286,"version":"3.40.5"},"reference-count":33,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T00:00:00Z","timestamp":1698278400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2024,3,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Sufficient vitamin D status is crucial for successful pregnancy and fetal development. The assessment of 25-hydroxyvitamin D (25(OH)D) concentrations is commonly used to evaluate vitamin D status. Our objective was to examine the interrelated biodynamics of maternal and neonatal total, free and bioavailable 25(OH)D in maternal\u2013neonatal dyads at birth and their associations with homeostasis and neonatal birth anthropometry. We analysed a cohort of seventy full-term mother\u2013child pairs. We found positive associations between all neonatal measures of vitamin D status. Maternal forms exhibited a similar pattern of association, except for the bioavailable maternal form. In multivariate analysis, both total and free maternal 25(OH)D concentrations were correlated with all neonatal forms (neonatal total 25(OH)D: 1\u00b729 (95 % CI, 1\u00b712, 1\u00b746) for maternal total 25(OH)D, 10\u00b789 (8\u00b716, 13\u00b763) for maternal free 25(OH)D), (neonatal free 25(OH)D: 0\u00b715 for maternal total 25(OH)D, 1\u00b728 (95 % CI, 0\u00b789, 1\u00b768) for maternal free 25(OH)D) and (0\u00b713 (95 % CI, 0\u00b710, 0\u00b716), 1\u00b706 (95 % CI, 0\u00b768, 1\u00b743) for maternal free 25(OH)D), respectively, with the exclusion of the bioavailable maternal form. We observed no significant interactions within or between groups regarding maternal and neonatal vitamin D parameters and maternal calcium\u00a0and parathyroid hormone concentrations, and neonatal birth anthropometry. Our study indicates that bioavailable maternal and neonatal 25(OH)D have no significant effects on vitamin D equilibrium, Ca homeostasis and neonatal anthropometry at birth. However, we observed an interaction between maternal and neonatal total and free 25(OH)D concentrations at the maternal\u2013neonatal interface, with no associations observed with other calciotropic or anthropometric outcomes.<\/jats:p>","DOI":"10.1017\/s000711452300243x","type":"journal-article","created":{"date-parts":[[2023,10,26]],"date-time":"2023-10-26T06:44:25Z","timestamp":1698302665000},"page":"801-808","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Associations of free, bioavailable and total 25-hydroxyvitamin D with neonatal birth anthropometry and calcium homoeostasis in mother\u2013child pairs in a sunny Mediterranean region"],"prefix":"10.1017","volume":"131","author":[{"given":"Hana M. A.","family":"Fakhoury","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6292-7683","authenticated-orcid":false,"given":"Tarek Ziad","family":"Arabi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani","family":"Tamim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rene F.","family":"Chun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1439-3285","authenticated-orcid":false,"given":"William B.","family":"Grant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Hewison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatme","family":"AlAnouti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Pilz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cedric","family":"Annweiler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Tzimagiorgis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costas","family":"Haitoglou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4225-2746","authenticated-orcid":false,"given":"Spyridon N.","family":"Karras","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2023,10,26]]},"reference":[{"key":"S000711452300243X_ref30","doi-asserted-by":"publisher","DOI":"10.3390\/nu10111631"},{"key":"S000711452300243X_ref3","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-14-0642"},{"key":"S000711452300243X_ref7","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051489"},{"key":"S000711452300243X_ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1475-2891-12-77"},{"key":"S000711452300243X_ref19","doi-asserted-by":"publisher","DOI":"10.1530\/EC-18-0432"},{"key":"S000711452300243X_ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.03.008"},{"key":"S000711452300243X_ref22","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/1408659"},{"key":"S000711452300243X_ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195700"},{"key":"S000711452300243X_ref4","first-page":"CD008873","article-title":"Vitamin 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Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}