{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T04:42:09Z","timestamp":1784004129797,"version":"3.55.0"},"reference-count":44,"publisher":"Cambridge University Press (CUP)","issue":"7","license":[{"start":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T00:00:00Z","timestamp":1700697600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2024,4,14]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During industrial processing, heat treatments applied to infant formulas may affect protein digestion. Recently, innovative processing routes have been developed to produce minimally heat-processed infant formula. Our objective was to compare the <jats:italic>in vivo<\/jats:italic> protein digestion kinetics and protein quality of a minimally processed (T\u2212) and a heat-treated (T+++) infant formula. Sixty-eight male Wistar rats (21 d) were fed with either a diet containing 40 % T\u2212 (<jats:italic>n<\/jats:italic> 30) or T+++ (<jats:italic>n<\/jats:italic> 30), or a milk protein control diet (<jats:italic>n<\/jats:italic> 8) during 2 weeks. T\u2212 and T+++ rats were then sequentially euthanised 0, 1, 2, 3 or 6 h (<jats:italic>n<\/jats:italic> 6\/time point) after ingestion of a meal containing their experimental diet. Control rats were euthanised 6 h after ingestion of a protein-free meal to determine nitrogen and amino acid endogenous losses. Nitrogen and amino acid true caecal digestibility was high for both T\u2212 and T+++ diets (&gt; 90 %), but a tendency towards higher nitrogen digestibility was observed for the T\u2212 diet (96\u00b76 \u00b1 3\u00b71 %) compared with the T+++ diet (91\u00b79 \u00b1 5\u00b74 %, <jats:italic>P<\/jats:italic> = 0\u00b70891). This slightly increased digestibility led to a greater increase in total amino acid concentration in plasma after ingestion of the T\u2212 diet (<jats:italic>P<\/jats:italic> = 0\u00b70010). Comparable protein quality between the two infant formulas was found with a digestible indispensable amino acid score of 0\u00b78. In conclusion, this study showed that minimal processing routes to produce native infant formula do not modify protein quality but tend to enhance its true nitrogen digestibility and increase postprandial plasma amino acid kinetics in rats.<\/jats:p>","DOI":"10.1017\/s0007114523002696","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T01:17:46Z","timestamp":1700702266000},"page":"1115-1124","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":9,"title":["Minimal processed infant formula <i>vs.<\/i> conventional shows comparable protein quality and increased postprandial plasma amino acid kinetics in rats"],"prefix":"10.1017","volume":"131","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1181-9786","authenticated-orcid":false,"given":"Juliane","family":"Calvez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Blais","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Am\u00e9lie","family":"Deglaire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Gaudichon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Blachier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Marie","family":"Davila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2023,11,23]]},"reference":[{"key":"S0007114523002696_ref26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-4614-3900-4_13","volume-title":"Linear Mixed-Effects Models Using R: A Step-by-Step Approach","author":"Ga\u0142ecki","year":"2013"},{"key":"S0007114523002696_ref33","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1093\/jn\/nxz279","article-title":"15N and (2)H intrinsic labeling demonstrate that real digestibility in rats of proteins and amino acids from sunflower protein isolate is almost as high as that of goat whey","volume":"150","author":"Tessier","year":"2020","journal-title":"J Nutr"},{"key":"S0007114523002696_ref22","unstructured":"22. FAO (2013) Dietary Protein Quality Evaluation in Human Nutrition. Report of an FAO Expert Consultation. Food and Nutrition Paper n\u00b092. 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