{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T20:24:22Z","timestamp":1782937462273,"version":"3.54.5"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2025,1,28]]},"abstract":"Abstract<\/jats:title>\n \n Prior observational studies have reported the potential protective effect of\n n<\/jats:italic>\n -3 fatty acids on the prognosis of acute pancreatitis (AP). However, the causal impact of\n n<\/jats:italic>\n -3 fatty acids on AP is unclear. We aimed to investigate further the association of\n n<\/jats:italic>\n -3 fatty acids with AP. We performed a meta-analysis and Mendelian randomisation (MR) to explore the association between\n n<\/jats:italic>\n -3 fatty acids and the prognosis of AP from clinical observation and genetics perspectives, respectively. Nine randomised controlled trials were included in this study. The result meta-analysis showed that complementary therapy of\n n<\/jats:italic>\n -3 fatty acids significantly decreased mortality (Relative Risk (RR): 0\u00b730; 95 % CI 0\u00b714, 0\u00b765,\n P<\/jats:italic>\n < 0\u00b705) and infectious complications in AP (RR: 0\u00b745; 95 % CI 0\u00b727, 0\u00b777,\n P<\/jats:italic>\n < 0\u00b705). Compared with the control groups, the hospital stays (MD: \u22121\u00b702; 95 % CI \u22121\u00b785, \u22120\u00b720,\n P<\/jats:italic>\n < 0\u00b705) in AP patients with\n n<\/jats:italic>\n -3 fatty acids treatment were statistically reduced. However, the ICU stay (MD: \u22120\u00b749; 95 % CI \u22121\u00b729, \u22120\u00b731,\n P<\/jats:italic>\n > 0\u00b705) between control groups and AP patients with\n n<\/jats:italic>\n -3 fatty acids treatment was insignificant. Utilising genetic susceptibility analysis in the MR approach, the MR showed\n n<\/jats:italic>\n -3 fatty acids have a significant causal effect on the AP risk (OR, 0\u00b7887; 95 % CI 0\u00b7797, 0\u00b7986,\n P<\/jats:italic>\n = 0\u00b7027, fixed-effect; OR, 0\u00b7887; 95 % CI 0\u00b7792, 0\u00b7993,\n P<\/jats:italic>\n = 0\u00b7037, random-effect).\n n<\/jats:italic>\n -3 fatty acids complementary therapy may improve the prognosis of AP. Furthermore, genetically predicted serum levels of\n n<\/jats:italic>\n -3 fatty acids can significantly lower AP risk.\n <\/jats:p>","DOI":"10.1017\/s0007114524002812","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T02:53:19Z","timestamp":1733712799000},"page":"221-230","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["The role of\n n<\/i>\n -3 fatty acids in acute pancreatitis"],"prefix":"10.1017","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-9037-8184","authenticated-orcid":false,"given":"Binbin","family":"Tang","sequence":"first","affiliation":[{"name":"Taizhou Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenyang","family":"Zhang","sequence":"additional","affiliation":[{"name":"Civil Aviation Hospital of Shanghai"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajun","family":"Gu","sequence":"additional","affiliation":[{"name":"Taizhou Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangde","family":"Miao","sequence":"additional","affiliation":[{"name":"Taizhou Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yu","sequence":"additional","affiliation":[{"name":"Taizhou Municipal Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2024,12,9]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114524002812","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:18:29Z","timestamp":1762507109000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114524002812\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,9]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,28]]}},"alternative-id":["S0007114524002812"],"URL":"https:\/\/doi.org\/10.1017\/s0007114524002812","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,9]]},"assertion":[{"value":"\u00a9 The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}