{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T10:44:54Z","timestamp":1776768294170,"version":"3.51.2"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T00:00:00Z","timestamp":1736294400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2025,1,28]]},"abstract":"Abstract<\/jats:title>\n \n An assessment of systemic inflammation and nutritional status may form the basis of a framework to examine the prognostic value of cachexia in patients with advanced cancer. The objective of the study was to examine the prognostic value of the Global Leadership Initiative on Malnutrition criteria, including BMI, weight loss (WL) and systemic inflammation (as measured by the modified Glasgow Prognostic Score (mGPS)), in advanced cancer patients. Three criteria were examined in a combined cohort of patients with advanced cancer, and their relationship with survival was examined using Cox regression methods. Data were available on 1303 patients. Considering BMI and the mGPS, the 3-month survival rate varied from 74 % (BMI > 28 kg\/m\n 2<\/jats:sup>\n ) to 61 % (BMI < 20 kg\/m\n 2<\/jats:sup>\n ) and from 84 % (mGPS 0) to 60 % (mGPS 2). Considering WL and the mGPS, the 3-month survival rate varied from 81 % (WL \u00b1 2\u00b74 %) to 47 % (WL \u2265 15 %) and from 93 % (mGPS 0) to 60 % (mGPS 2). Considering BMI\/WL grade and mGPS, the 3-month survival rate varied from 86 % (BMI\/WL grade 0) to 59 % (BMI\/WL grade 4) and from 93 % (mGPS 0) to 63 % (mGPS 2). When these criteria were combined, they better predicted survival. On multivariate survival analysis, the most highly predictive factors were BMI\/WL grade 3 (HR 1\u00b7454,\n P<\/jats:italic>\n = 0\u00b7004), BMI\/WL grade 4 (HR 2\u00b7285,\n P<\/jats:italic>\n < 0\u00b7001) and mGPS 1 and 2 (HR 1\u00b7889, HR 2\u00b7545, all\n P<\/jats:italic>\n < 0\u00b7001). In summary, a high BMI\/WL grade and a high mGPS as outlined in the BMI\/WL grade\/mGPS framework were consistently associated with poorer survival of patients with advanced cancer. It can be readily incorporated into the routine assessment of patients.\n <\/jats:p>","DOI":"10.1017\/s0007114524003271","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T05:13:32Z","timestamp":1736313212000},"page":"246-252","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Prognostic value of the Global Leadership Initiative on Malnutrition criteria including systemic inflammation in patients with advanced cancer"],"prefix":"10.1017","volume":"133","author":[{"given":"Bruna M. M.","family":"Rocha","sequence":"first","affiliation":[{"name":"Federal University of Uberlandia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josh","family":"McGovern","sequence":"additional","affiliation":[{"name":"University of Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos E.","family":"Paiva","sequence":"additional","affiliation":[{"name":"Palliative Care and Quality of Life Research Group (GPQual)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ross D.","family":"Dolan","sequence":"additional","affiliation":[{"name":"University of Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bianca S. R.","family":"Paiva","sequence":"additional","affiliation":[{"name":"Palliative Care and Quality of Life Research Group (GPQual)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel D.","family":"Preto","sequence":"additional","affiliation":[{"name":"Palliative Care and Quality of Life Research Group (GPQual)"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry J.","family":"Laird","sequence":"additional","affiliation":[{"name":"University of Edinburgh"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9169-5028","authenticated-orcid":false,"given":"Yara C. P.","family":"Maia","sequence":"additional","affiliation":[{"name":"Federal University of Uberlandia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald C.","family":"McMillan","sequence":"additional","affiliation":[{"name":"University of Glasgow"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,1,8]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114524003271","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:18:23Z","timestamp":1762507103000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114524003271\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1,8]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,1,28]]}},"alternative-id":["S0007114524003271"],"URL":"https:\/\/doi.org\/10.1017\/s0007114524003271","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1,8]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}