{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:33:21Z","timestamp":1790033601749,"version":"4.0.1"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>This study aims to assess the therapeutic effects of probiotic oral therapy in paediatric patients with anorexia nervosa (AN) and to investigate its impact on intestinal flora composition, brain\u2013gut peptide levels and overall clinical outcomes. A retrospective study was conducted involving 100 children diagnosed with AN at Xingtang County People\u2019s Hospital between January 2023 and June 2024. Patients were divided into two groups: a control group (<jats:italic>n<\/jats:italic> 50) receiving zinc gluconate oral solution alone and an observation group (<jats:italic>n<\/jats:italic> 50) receiving zinc gluconate plus probiotics. Outcome measures included intestinal flora analysis, brain\u2013gut peptide levels (somatostatin (SS) and nitric oxide (NO)), clinical efficacy, serum trace element levels (Ca, Zn and Fe) and prognosis, including recurrence rates 6 months post-treatment. Baseline characteristics were similar between the two groups (<jats:italic>P<\/jats:italic> &gt; 0\u00b705). After treatment, the observation group showed significantly higher levels of Bifidobacterium and Lactobacillus and lower levels of Enterobacter compared with the control group (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Additionally, the observation group had lower levels of SS and NO (<jats:italic>P<\/jats:italic> &lt; 0\u00b705), indicating improved brain\u2013gut communication. Clinical efficacy was significantly higher in the observation group (<jats:italic>P<\/jats:italic> &lt; 0\u00b705), with improved serum trace element levels (<jats:italic>P<\/jats:italic> &lt; 0\u00b705 for Ca, Zn and Fe). Furthermore, the recurrence rate 6 months post-treatment was significantly lower in the observation group compared with the control group (<jats:italic>P<\/jats:italic> &lt; 0\u00b705). Probiotic supplementation in children with AN effectively modulates intestinal flora, improves brain\u2013gut peptide levels and enhances clinical outcomes.<\/jats:p>","DOI":"10.1017\/s0007114525000169","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T09:16:36Z","timestamp":1738919796000},"page":"491-496","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":4,"title":["Effects of probiotic supplementation on intestinal flora, brain\u2013gut peptides and clinical outcomes in children with anorexia nervosa"],"prefix":"10.1017","volume":"133","author":[{"given":"Xiaoyan","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0038-1686","authenticated-orcid":false,"given":"Yali","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longxia","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junqiong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linjuan","family":"Hua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,2,7]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114525000169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:35:23Z","timestamp":1744713323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114525000169\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,7]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2,28]]}},"alternative-id":["S0007114525000169"],"URL":"https:\/\/doi.org\/10.1017\/s0007114525000169","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,7]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}