{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T04:20:05Z","timestamp":1744777205082,"version":"3.40.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Insulin-like growth factor 1 (IGF-1) is an important growth factor in childhood. We aimed to investigate the impact of food supplements for the treatment of moderate acute malnutrition (MAM) on serum IGF-1 (sIGF-1). Secondary analysis of a randomised 2 \u00d7 2 \u00d7 3 factorial nutrition trial was performed. Children aged 6\u201323 months with MAM received 2093 kJ\/d as lipid-based nutrient supplement (LNS) or corn soy blend (CSB), containing either dehulled soya or soya isolate and different quantities of dried skimmed milk (0 %, 20 % or 50 % of total protein) for 12 weeks. The trial was double-blind with regard to soya and milk but not to matrix (LNS <jats:italic>v<\/jats:italic>. CSB). sIGF-1 was measured at inclusion and after 12 weeks of supplementation. Of 1609 children enrolled, 1455 (90 %) had sIGF-1 measured at both time points. During supplementation, sIGF-1 increased 6\u00b77 (95 % CI 6\u00b71, 7\u00b73) ng\/ml compared with an expected age-dependent decrease of 0\u00b73 (95 % CI 0\u00b72, 0\u00b74) ng\/ml. Children who received LNS <jats:italic>v<\/jats:italic>. CSB had a lower increase in sIGF-1 (\u20138 %, 95 % CI \u2212 12, \u22123). The effect of LNS was partly attenuated when sIGF-1 was corrected for inflammation. Children who received soya isolate compared with dehulled soya had a higher increase in sIGF-1 (6 %, 95 % CI 1, 12). Milk content did not affect sIGF-1. Overall, sIGF-1 increased during supplementation. The lower increase with LNS <jats:italic>v<\/jats:italic>. CSB was only partly explained by increased inflammation with LNS and needs further investigation. Isolate <jats:italic>v<\/jats:italic>. dehulled soya led to a higher increase which may be due to antinutrients in dehulled soya.<\/jats:p>","DOI":"10.1017\/s0007114525000212","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T04:14:56Z","timestamp":1739420096000},"page":"481-490","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Serum insulin-like growth factor 1 in young children with moderate acute malnutrition: secondary analysis of a randomised trial in Burkina Faso"],"prefix":"10.1017","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-8839","authenticated-orcid":false,"given":"Thora W.","family":"Helt","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardette","family":"Cichon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Fabiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann-Sophie","family":"Iuel-Brockdorff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles W.","family":"Yam\u00e9ogo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-0624","authenticated-orcid":false,"given":"Christian","family":"Ritz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9","family":"Briend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kim F.","family":"Michaelsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-6825","authenticated-orcid":false,"given":"Suzanne","family":"Filteau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke B.","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0259-7851","authenticated-orcid":false,"given":"Benedikte","family":"Grenov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"56","published-online":{"date-parts":[[2025,2,13]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114525000212","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T10:35:23Z","timestamp":1744713323000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114525000212\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":0,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,2,28]]}},"alternative-id":["S0007114525000212"],"URL":"https:\/\/doi.org\/10.1017\/s0007114525000212","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"type":"print","value":"0007-1145"},{"type":"electronic","value":"1475-2662"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}