{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T05:09:35Z","timestamp":1791608975899,"version":"4.3.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T00:00:00Z","timestamp":1739404800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2025,3,14]]},"abstract":"Abstract<\/jats:title>A randomised parallel intervention study was conducted with male patients diagnosed with CHD. Participants were assigned to three groups: Group A abstained from alcohol (n<\/jats:italic> 20), Group B consumed red wine (n<\/jats:italic> 21) and Group C (n<\/jats:italic> 16) consumed an alcoholic beverage without wine micro-constituents. Biological samples were collected at baseline, 4 and 8 weeks. Enzyme activities of acetyl-CoA:lyso-platelet-activating factor (PAF) acetyltransferase, cytidine 5\u2019-diphospho (CDP)-choline:1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase (PAF-cholinephosphotransferase), PAF-acetylhydrolase in leukocyte homogenates, serum lipoprotein-associated phospholipase-A2<\/jats:sub> and plasma markers of thrombosis were measured. PAF-, ADP- and collagen-induced platelet aggregation was measured in human platelet-rich plasma. Red wine consumption led to a 15\u00b73 % reduction in LysoPAF-acetyltransferase activity at 4 weeks (P<\/jats:italic>= 0\u00b7008) compared with baseline and Group A (P<\/jats:italic>= 0\u00b701). PAF-cholinephosphotransferase activity was reduced by 11\u00b71 % at 8 weeks (P<\/jats:italic>= 0\u00b704) compared with baseline and by 24\u00b79 % compared with Group C (P<\/jats:italic>= 0\u00b702). PAF-acetylhydrolase activity was reduced by 36\u00b72 % at 8 weeks compared with baseline (P<\/jats:italic>= 0\u00b7001) and compared with Group A (P<\/jats:italic>< 0\u00b7000) and Group C (P<\/jats:italic>= 0\u00b7009). Fibrinogen levels in Group B reduced by 6\u20139 % at 4 (P<\/jats:italic>= 0\u00b704) and 8 weeks (P<\/jats:italic>= 0\u00b701) compared with baseline while D-dimer in Group C increased by 16\u00b71 % at 8 weeks (P<\/jats:italic>= 0\u00b7005) compared with baseline. Platelet aggregation against PAF and collagen was reduced in Group B (82\u00b76 and 35\u00b74 %, respectively), and in Group C (158\u00b74 and 37\u00b71 %, respectively) compared with baseline and Group A (P<\/jats:italic>< 0\u00b705). In conclusion, moderate wine consumption improved the activity of PAF-metabolism enzymes regardless of ethanol and reduced platelet aggregation, probably through mechanisms different from those of ethanol.<\/jats:p>","DOI":"10.1017\/s0007114525000273","type":"journal-article","created":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T04:14:47Z","timestamp":1739420087000},"page":"600-610","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":5,"title":["Effect of moderate wine consumption on the activity of enzymes involved in platelet-activating factor metabolism and thrombotic biomarkers: a randomised, single-blind, parallel, clinical study in CHD men patients"],"prefix":"10.1017","volume":"133","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-9711","authenticated-orcid":false,"given":"Elizabeth","family":"Fragopoulou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysa","family":"Argyrou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Matalliotaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Pafilas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Detopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7071-5920","authenticated-orcid":false,"given":"Smaragdi","family":"Antonopoulou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Genovefa","family":"Kolovou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Kalogeropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,2,13]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114525000273","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,6]],"date-time":"2025-05-06T09:10:49Z","timestamp":1746522649000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114525000273\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2,13]]},"references-count":0,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025,3,14]]}},"alternative-id":["S0007114525000273"],"URL":"https:\/\/doi.org\/10.1017\/s0007114525000273","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,13]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}