{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T05:57:44Z","timestamp":1789106264322,"version":"build-2803163510"},"reference-count":67,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"abstract":"<jats:title>Abstract<\/jats:title>\n\t  <jats:p>The World Cancer Research Fund and the American Institute for Cancer Research recommend a plant-based diet to cancer survivors, which may reduce chronic inflammation and excess adiposity associated with worse survival. We investigated associations of plant-based dietary patterns with inflammation biomarkers and body composition in the Pathways Study, in which 3659 women with breast cancer provided validated food frequency questionnaires approximately 2 months after diagnosis. We derived three plant-based diet indices: overall plant-based diet index (PDI), healthful plant-based diet index (hPDI)\u00a0and unhealthful plant-based diet index (uPDI). We assayed circulating inflammation biomarkers related to systemic inflammation (high-sensitivity C-reactive protein [hsCRP]), pro-inflammatory cytokines (IL-1\u03b2, IL-6, IL-8, TNF-\u03b1) and anti-inflammatory cytokines (IL-4, IL-10, IL-13). We estimated areas (cm<jats:sup>2<\/jats:sup>) of muscle and visceral and subcutaneous adipose tissue (VAT and SAT)\u00a0from computed tomography scans. Using multivariable linear regression, we calculated the differences in inflammation biomarkers and body composition for each index. Per 10-point increase for each index: hsCRP was significantly lower by 6\u00b79 % (95 % CI\u00a01\u00b76%, 11\u00b78%) for PDI and 9\u00b70 % (95 % CI 4\u00b79%, 12\u00b78%) for hPDI but significantly higher by 5\u00b74 % (95 % CI\u00a00\u00b75%, 10\u00b75%) for uPDI, and VAT was significantly lower by 7\u00b78 cm<jats:sup>2<\/jats:sup> (95 % CI 2\u00b70 cm<jats:sup>2<\/jats:sup>, 13\u00b76 cm<jats:sup>2<\/jats:sup>) for PDI and 8\u00b76 cm<jats:sup>2<\/jats:sup> (95 % CI 4\u00b71 cm<jats:sup>2<\/jats:sup>, 13\u00b72 cm<jats:sup>2<\/jats:sup>) for hPDI but significantly higher by 6\u00b72 cm<jats:sup>2<\/jats:sup> (95 % CI 1\u00b73 cm<jats:sup>2<\/jats:sup>, 11\u00b71 cm<jats:sup>2<\/jats:sup>) for uPDI. No significant associations were observed for other inflammation biomarkers, muscle, or SAT. A plant-based diet, especially a healthful plant-based diet, may be associated with reduced inflammation and visceral adiposity among breast cancer survivors.<\/jats:p>","DOI":"10.1017\/s0007114525000856","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T07:59:30Z","timestamp":1747641570000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":6,"title":["Plant-based diet, inflammation biomarkers and body composition among women with breast cancer: the Pathways Study"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9523-9310","authenticated-orcid":false,"given":"En","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chen","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac J.","family":"Ergas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bette J.","family":"Caan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilyn L.","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janise M.","family":"Roh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting-Yuan David","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitika J.","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph R.","family":"Hanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans","family":"Minderman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyang","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil M.","family":"Iyengar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine B.","family":"Ambrosone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence H.","family":"Kushi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"Cespedes Feliciano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"S0007114525000856_ref3","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/137.1.243S"},{"key":"S0007114525000856_ref14","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.18.9068"},{"key":"S0007114525000856_ref60","unstructured":"60. 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