{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T15:17:36Z","timestamp":1761837456427,"version":"build-2065373602"},"reference-count":41,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T00:00:00Z","timestamp":1756252800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2025,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    B vitamin and methionine intake may influence cancer development, but their link to gastric cancer (GC) risk is unclear. Nutrients related to one-carbon metabolism (OCM) have been shown to be associated with\n                    <jats:italic>S<\/jats:italic>\n                    -adenosylhomocysteine hydrolase (AHCY), one of the most crucial enzymes in OCM, which is regulated by the\n                    <jats:italic>AHCY<\/jats:italic>\n                    gene. Thus, we hypothesised that a higher intake of total nutrients related to OCM may reduce the risk of GC, and this preventative effect may interact with the\n                    <jats:italic>AHCY<\/jats:italic>\n                    rs819173 polymorphism. We conducted a case\u2013control study at the National Cancer Center in Korea, involving 371 cases and 738 controls, aiming to determine the interaction between the\n                    <jats:italic>AHCY<\/jats:italic>\n                    rs819173 polymorphism and nutrients related to OCM intakes in GC risk. Dietary vitamin B and methionine intakes were collected using semi-quantitative FFQ (SQFFQ). The OR and 95 % CI were calculated using unconditional logistic regression models. Higher intake of total nutrients related to OCM was found to be inversely associated with GC risk (adjusted OR (aOR) = 0\u00b757, 95 % CI 0\u00b737, 0\u00b786,\n                    <jats:italic>P<\/jats:italic>\n                    <jats:sub>for trend<\/jats:sub>\n                    = 0\u00b7009). No significant association between the\n                    <jats:italic>AHCY<\/jats:italic>\n                    rs819173 polymorphism and GC risk was found. In the dominant model of\n                    <jats:italic>AHCY<\/jats:italic>\n                    rs819173, participants with major homozygous (TT) and higher intake of nutrients related to OCM had a lower GC risk than those with lower intake (aOR = 0\u00b749, 95 % CI 0\u00b730, 0\u00b781,\n                    <jats:italic>P<\/jats:italic>\n                    interaction = 0\u00b7015). Higher intakes of total vitamin B and methionine were proposed as potential protective nutrients against GC. Moreover, this association might be influenced by the presence of the\n                    <jats:italic>AHCY<\/jats:italic>\n                    rs819173 polymorphism.\n                  <\/jats:p>","DOI":"10.1017\/s0007114525103528","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T07:56:21Z","timestamp":1756281381000},"page":"353-363","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Interaction between dietary nutrients related to one-carbon metabolism intakes and\n                    <i>AHCY<\/i>\n                    rs819173 polymorphism in the risk of gastric cancer: a case\u2013control study in Korea"],"prefix":"10.1017","volume":"134","author":[{"given":"Ha Thi Mien","family":"Nguyen","sequence":"first","affiliation":[{"name":"Graduate School of Cancer Science and 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