{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T20:36:12Z","timestamp":1782246972661,"version":"3.54.5"},"reference-count":61,"publisher":"Cambridge University Press (CUP)","issue":"6","license":[{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2025,9,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Age is the main risk factor for many neurodegenerative diseases such as Alzheimer\u2019s disease, Parkinson\u2019s disease and frontotemporal dementia. Despite our limited understanding of cellular mechanisms of ageing-associated neuronal loss, an increasing number of studies demonstrate that oxidative stress and inflammation are key drivers. Epidemiological studies indicate that diet during middle adulthood can influence the risk of developing neurodegenerative diseases later in life, so it is important to investigate dietary interventions to combat oxidative stress and inflammation. In this study, we hypothesised that treatment with fucoxanthin, a marine carotenoid with strong antioxidant properties, prevents ageing-associated oxidative stress that is known to be related to natural brain ageing. Treatment with fucoxanthin protected rat primary hippocampal neurons against oxidative stress and ageing\n                    <jats:italic>in vitro<\/jats:italic>\n                    . In our\n                    <jats:italic>in vivo<\/jats:italic>\n                    study, middle-aged male Sprague-Dawley rats were gavaged with fucoxanthin (1 mg\/kg, 5 d\/week,\n                    <jats:italic>n<\/jats:italic>\n                    6) or vehicle (\n                    <jats:italic>n<\/jats:italic>\n                    6) for 4 weeks. After supplementation was completed, brain samples were harvested and subjected to quantitative and bioinformatic analyses. Fucoxanthin was detected and shown to decrease lipid peroxidation in the brains of the animals supplemented with fucoxanthin. Microarray analysis showed that treatment with fucoxanthin changed 5602 genes. Together, our results suggest that treatment with fucoxanthin prevents ageing-associated oxidative stress and is capable of regulating genes that potentially ameliorate age-related changes to the brain.\n                  <\/jats:p>","DOI":"10.1017\/s0007114525104996","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T07:31:38Z","timestamp":1756884698000},"page":"451-461","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Oral supplementation of fucoxanthin regulates gene expression in the brain of middle-aged rats"],"prefix":"10.1017","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5563-5255","authenticated-orcid":false,"given":"Han-A","family":"Park","sequence":"first","affiliation":[{"name":"The University of Alabama"},{"name":"The University of Alabama"},{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Amjad","sequence":"additional","affiliation":[{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Garrett","family":"Burnett","sequence":"additional","affiliation":[{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khondoker Adeba","family":"Ferdous","sequence":"additional","affiliation":[{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madison","family":"Scott","sequence":"additional","affiliation":[{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Jansen","sequence":"additional","affiliation":[{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sydni","family":"Bannerman","sequence":"additional","affiliation":[{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Scott","sequence":"additional","affiliation":[{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N.","family":"Correll","sequence":"additional","affiliation":[{"name":"The University of Alabama"},{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukasz","family":"Ciesla","sequence":"additional","affiliation":[{"name":"The University of Alabama"},{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Ellis","sequence":"additional","affiliation":[{"name":"The University of Alabama"},{"name":"The University of Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,9,3]]},"reference":[{"key":"S0007114525104996_ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2014.01.002"},{"key":"S0007114525104996_ref1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-019-0244-7"},{"key":"S0007114525104996_ref15","doi-asserted-by":"publisher","DOI":"10.3390\/md10081784"},{"key":"S0007114525104996_ref32","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.07-0208"},{"key":"S0007114525104996_ref39","doi-asserted-by":"publisher","DOI":"10.4103\/0976-0105.177703"},{"key":"S0007114525104996_ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2014.10.004"},{"key":"S0007114525104996_ref2","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer\u2019s disease facts and figures","volume":"20","author":"Dement","year":"2024","journal-title":"Alzheimers Dement"},{"key":"S0007114525104996_ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.nutres.2022.02.007"},{"key":"S0007114525104996_ref33","doi-asserted-by":"publisher","DOI":"10.1201\/b10320"},{"key":"S0007114525104996_ref26","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2007.145409"},{"key":"S0007114525104996_ref51","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101416"},{"key":"S0007114525104996_ref34","doi-asserted-by":"publisher","DOI":"10.1016\/j.dscb.2021.100016"},{"key":"S0007114525104996_ref20","doi-asserted-by":"publisher","DOI":"10.3390\/md20040245"},{"key":"S0007114525104996_ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.12.032"},{"key":"S0007114525104996_ref4","unstructured":"4. 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