{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T14:10:08Z","timestamp":1788099008992,"version":"build-2803163510"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"9","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2025,11,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Thyroglobulin (Tg) has been considered a measure of iodine status, but there is no global guidance. This analysis examines the relationship between serum Tg and spot urinary iodine concentration (UIC) data to identify Tg concentrations that correspond to current WHO thresholds for population iodine status. We analysed data from 730 non-pregnant Guatemalan women aged 15\u201349 years who had both UIC and Tg measurements. Correlations were examined. Bootstrap stratified finite sampling with replacement was used to generate cluster\n                    <jats:italic>k-medians<\/jats:italic>\n                    of UIC (mUIC) and Tg (mTg) that served as the population unit of analyses. Non-linear restricted cubic spline regression dose\u2013response curve functions and ordinary differential equations were then used to derive the Tg threshold corresponding to WHO definitions for UIC. Mean age was 30\u00b72 (\n                    <jats:sc>sd<\/jats:sc>\n                    9\u00b73) years. mTg was 10\u00b74 ng\/ml (9\u00b79, 10\u00b78), and mUIC was 148\u00b77 \u03bcg\/l (139\u00b71, 161\u00b70). Correlations between spot UIC and Tg were NS at the individual level, but correlations based on population\n                    <jats:italic>k-medians<\/jats:italic>\n                    were significant (Spearman\n                    <jats:italic>r<\/jats:italic>\n                    = \u22120\u00b721 to \u22120\u00b706, each\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b70001) and demonstrated a\n                    <jats:italic>U<\/jats:italic>\n                    -shaped relationship according to WHO categories. Derived mTg cutoffs were 14\u00b72 ng\/ml predictive of UIC insufficiency, 10\u00b72 ng\/ml for UIC adequacy, 8\u00b75 ng\/ml for UIC above adequate and 10\u00b78 ng\/ml for UIC excess. The significant and graded mUIC\u2013mTg correlations suggest that Tg concentrations predictive of UIC categories are obtainable for non-pregnant Guatemalan women aged 15\u201349 years. The newly derived mTg cutoff may be more discriminant at a lower spectrum of UIC in terms of identifying iodine-deficient women, more so than in the UIC excess category.\n                  <\/jats:p>","DOI":"10.1017\/s0007114525105205","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T05:33:53Z","timestamp":1758864833000},"page":"705-711","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Serum thyroglobulin levels are predictive of urinary iodine concentration thresholds for defining population iodine status"],"prefix":"10.1017","volume":"134","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8500-630X","authenticated-orcid":false,"given":"Kasthuri","family":"Sivalogan","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University"},{"name":"USA Centers for Disease Control and Prevention (CDC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael","family":"Flores-Ayala","sequence":"additional","affiliation":[{"name":"USA Centers for Disease Control and Prevention (CDC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roelinda","family":"Jongstra","sequence":"additional","affiliation":[{"name":"USA Centers for Disease Control and Prevention (CDC)"},{"name":"McKing Consulting Corporation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Martinez","sequence":"additional","affiliation":[{"name":"Institute of Nutrition of Central America and Panama (INCAP-Guatemala)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Secretariat of Food and Nutrition"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireya","family":"Palmieri","sequence":"additional","affiliation":[{"name":"Institute of Nutrition of Central America and Panama (INCAP-Guatemala)"},{"name":"Secretariat of Food and Nutrition"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karla","family":"Mesarina","sequence":"additional","affiliation":[{"name":"Institute of Nutrition of Central America and Panama (INCAP-Guatemala)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Elena","family":"Jefferds","sequence":"additional","affiliation":[{"name":"USA Centers for Disease Control and Prevention (CDC)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1269-759X","authenticated-orcid":false,"given":"O. Yaw","family":"Addo","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University"},{"name":"USA Centers for Disease Control and Prevention (CDC)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,9,26]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114525105205","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T13:30:51Z","timestamp":1767360651000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114525105205\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,26]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,11,14]]}},"alternative-id":["S0007114525105205"],"URL":"https:\/\/doi.org\/10.1017\/s0007114525105205","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,26]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}