{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T08:58:20Z","timestamp":1785401900667,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T00:00:00Z","timestamp":1763337600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2026,1,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Children with moderate acute malnutrition (MAM) have an increased risk of iron deficiency, anaemia and death from infectious diseases. The iron-regulating hormone hepcidin is increased in inflammation and may be important in regulating iron metabolism in children with MAM. Asymptomatic malaria has previously been associated with elevated s-hepcidin. We assessed the association between inflammation, iron status, anthropometry and malaria and serum hepcidin (s-hepcidin) and evaluated the effect of food supplementation on s-hepcidin in a secondary analysis in 1019 children with MAM from a randomised intervention trial in Burkina Faso. Children received 12 weeks of supplementation of 500 kcal\/d as either corn\u2013soy blend (CSB) or lipid-based nutritional supplements (LNS). S-hepcidin was measured at baseline and after 12 weeks. At baseline, correlates of s-hepcidin were determined using Tobit regression. The effect of supplementation was determined using mixed effects Tobit regression. Children with iron deficiency had 82 % (95 % CI 76, 87) lower s-hepcidin than those without, whereas children with acute infection and inflammation had elevated s-hepcidin. Children with symptomatic malaria had 103 % (95 % CI 32, 210) higher s-hepcidin than afebrile children without detectable malaria, while children with recent or asymptomatic malaria had 51 % (95 % CI 35, 63) lower s-hepcidin. S-hepcidin increased 61 % (95 % CI 38, 87) after 12 weeks of food supplementation with 22 % higher (95 % CI 2, 45) concentration in those who received LNS compared with CSB. Expectedly, morbidity and inflammation were associated with higher, and iron deficiency with lower, s-hepcidin. Further studies are needed to corroborate the finding of decreased s-hepcidin in malnourished children with asymptomatic malaria.<\/jats:p>","DOI":"10.1017\/s0007114525105679","type":"journal-article","created":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T05:54:14Z","timestamp":1763358854000},"page":"167-177","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Hepcidin is low in children with moderate acute malnutrition and asymptomatic malaria: secondary analysis of a 2\u00d72\u00d73 factorial randomised trial in Burkina Faso"],"prefix":"10.1017","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3763-8839","authenticated-orcid":false,"given":"Thora W.","family":"Helt","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/035b05819","id-type":"ROR","asserted-by":"publisher"}],"name":"Copenhagen University Hospital \u2013 Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rgen","family":"Kurtzhals","sequence":"additional","affiliation":[{"name":"University of Copenhagen"},{"name":"Copenhagen University Hospital \u2013 Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karoline K.","family":"List","sequence":"additional","affiliation":[{"name":"Copenhagen University Hospital \u2013 Rigshospitalet"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bjarne","family":"Styrishave","sequence":"additional","affiliation":[{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles W.","family":"Yam\u00e9ogo","sequence":"additional","affiliation":[{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Fabiansen","sequence":"additional","affiliation":[{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann-Sophie","family":"Iuel-Brockdorf","sequence":"additional","affiliation":[{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5095-0624","authenticated-orcid":false,"given":"Christian","family":"Ritz","sequence":"additional","affiliation":[{"name":"The National Institute of Public Health, University of Southern Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Briend","sequence":"additional","affiliation":[{"name":"University of Copenhagen"},{"name":"Tampere University and Tampere University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1119-6825","authenticated-orcid":false,"given":"Suzanne","family":"Filteau","sequence":"additional","affiliation":[{"name":"London School of Hygiene and Tropical Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim F.","family":"Michaelsen","sequence":"additional","affiliation":[{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Friis","sequence":"additional","affiliation":[{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vibeke B.","family":"Christensen","sequence":"additional","affiliation":[{"name":"M\u00e9decins Sans Fronti\u00e8res-Denmark"},{"name":"Copenhagen University Hospital \u2013 Rigshospitalet"},{"name":"University of Copenhagen"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,17]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114525105679","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T11:32:06Z","timestamp":1770636726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114525105679\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,17]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,28]]}},"alternative-id":["S0007114525105679"],"URL":"https:\/\/doi.org\/10.1017\/s0007114525105679","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,17]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use and\/or adaptation of the article.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}