{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:49:44Z","timestamp":1791618584286,"version":"4.3.4"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","issue":"2","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2026,1,28]]},"abstract":"Abstract<\/jats:title>\n \n Polycystic ovary syndrome is a disorder characterised by insulin resistance, low-grade inflammation and increased adipose tissue. The very low-carbohydrate ketogenic diet has been suggested to reduce obesity risks in polycystic ovary syndrome. This study aimed to update the evidence on the effects of the very low-carbohydrate ketogenic diet in women with polycystic ovary syndrome. Searches were conducted in electronic databases for randomised clinical trials addressing the research question. The values for the meta-analysis were presented as weighted mean difference (WMD). Twelve studies were included in the qualitative analysis and eleven in the quantitative analysis. Significant reductions were observed in anthropometric outcomes: weight (WMD: \u22129\u00b757 kg;\n P<\/jats:italic>\n < 0\u00b70001), waist circumference (WMD: \u22127\u00b775 cm;\n P<\/jats:italic>\n < 0\u00b70009), fat body mass (WMD: \u22127\u00b744 kg;\n P<\/jats:italic>\n = 0\u00b70008), BMI (WMD: \u22123\u00b745 kg\/m\n 2<\/jats:sup>\n ;\n P<\/jats:italic>\n < 0\u00b70001) and waist-to-hip ratio (WMD: \u22120\u00b702;\n P<\/jats:italic>\n < 0\u00b70034). Hormonal improvements included free testosterone (WMD: \u22120\u00b731 ng\/dl;\n P<\/jats:italic>\n < 0\u00b70001), total testosterone (WMD: \u22127\u00b721 ng\/dl;\n P<\/jats:italic>\n < 0\u00b70001), sex hormone-binding globulin (WMD: 15\u00b722 nmol\/l;\n P<\/jats:italic>\n = 0\u00b70035), luteinising hormone (WMD:\u00a0\u22123\u00b797 U\/L;\n P<\/jats:italic>\n = 0\u00b70008) and luteinising hormone:follicle-stimulating hormone ratio (WMD: \u22121\u00b704;\n P<\/jats:italic>\n = 0\u00b70053), but not for follicle-stimulating hormone levels (WMD: 1\u00b723 mUI\/ml;\n P<\/jats:italic>\n = 0\u00b712). Significant changes in metabolic markers were seen in blood glucose (WMD: \u22129\u00b765 mg\/dl;\n P<\/jats:italic>\n = 0\u00b70031), insulin (WMD: \u22122\u00b741 mg\/dl;\n P<\/jats:italic>\n = 0\u00b70387), homeostatic model assessment for insulin resistance (WMD: \u22122\u00b746;\n P<\/jats:italic>\n = 0\u00b70123) and TAG (WMD: \u221229\u00b795 mg\/dl;\n P<\/jats:italic>\n = 0\u00b70188). The very low-carbohydrate ketogenic diet shows significant benefits in managing body composition, reducing hyperandrogenism, balancing sex hormones and improving glucose metabolism in polycystic ovary syndrome.\n <\/jats:p>","DOI":"10.1017\/s0007114525105692","type":"journal-article","created":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T04:06:14Z","timestamp":1763438774000},"page":"178-193","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":3,"title":["Effects of the very low-carbohydrate ketogenic diet in women with polycystic ovary syndrome: a systematic review with meta-analysis of clinical trials"],"prefix":"10.1017","volume":"135","author":[{"given":"J\u00e9ssica Abdo Gon\u00e7alves","family":"Tosatti","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0176yjw32","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Medeiros Vale","family":"Magalh\u00e3es","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0176yjw32","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6870-2063","authenticated-orcid":false,"given":"Karina Braga","family":"Gomes","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/0176yjw32","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal de Minas Gerais"},{"id":[{"id":"https:\/\/ror.org\/0176yjw32","id-type":"ROR","asserted-by":"publisher"}],"name":"Universidade Federal de Minas Gerais"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2025,11,18]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114525105692","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T11:32:06Z","timestamp":1770636726000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114525105692\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,1,28]]}},"alternative-id":["S0007114525105692"],"URL":"https:\/\/doi.org\/10.1017\/s0007114525105692","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"assertion":[{"value":"\u00a9 The Author(s), 2025. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}