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This study examined the effects of ingesting AIN-93M purified diet (PD) on gut immune function and gut microbiota in DO11\u00b710 mice, in which T cell\u2013dependent and T cell\u2013independent (TI) IgA can be analysed separately. Ingestion of the PD for 2 weeks reduced both T cell\u2013dependent and TI secretory IgA in the faeces compared with non-PD, whereas the diet did not affect T cell\u2013dependent and TI serum IgA. Ingestion of the PD had no effect on systemic immune system splenocyte responses. Ingestion of the PD reduced intestinal tissue expression levels of B-cell activating factor and A proliferation\u2013inducing ligand, cytokines involved in TI-IgA production and polymeric Ig receptor, which transports IgA into the intestinal lumen. Co-abundance group (CAG) analysis of the intestinal microbiota was conducted based on correlations between changes in the abundance of bacterial genera, and the correlations between CAG and IgA were determined. The\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    -dominated CAG expanded following ingestion of the PD, accompanied by an inverse correlation with the decrease in faecal IgA, whereas the\n                    <jats:italic>Lactobacillus<\/jats:italic>\n                    -dominated CAG shrank relative to the\n                    <jats:italic>Allobaculum<\/jats:italic>\n                    -dominated CAG. These results suggest that TI-IgA suppresses the expansion of some intestinal bacteria and that ingestion of the PD induces dysbiosis via impaired IgA secretion into the intestinal lumen.\n                  <\/jats:p>","DOI":"10.1017\/s0007114525105916","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T05:44:52Z","timestamp":1765950292000},"page":"276-285","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Purified diet reduces intestinal IgA and alters the microbiota 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Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}