{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T12:12:47Z","timestamp":1785413567433,"version":"3.56.0"},"reference-count":36,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Coconut oil, extracted from coconut kernels, is a rich source of medium-chain fatty acids, including lauric acid, capric acid and caprylic acid. This experiment aimed to investigate the protective effect of coconut oil against intestinal injury induced by lipopolysaccharide (LPS) challenge in piglets. A total of twenty-four piglets were used in a 2 \u00d7 2 factorial experiment with dietary treatment (3 % soybean oil\n                    <jats:italic>v<\/jats:italic>\n                    . 3 % coconut oil) and LPS challenge (saline\n                    <jats:italic>v<\/jats:italic>\n                    . LPS). After 28 d of the experiment, piglets were injected intraperitoneally with LPS (100 \u03bcg\/kg body weight (BW)) or saline. Piglets were slaughtered and sampled for testing. Pigs fed coconut oil had higher average daily gain and BW during the entire study. Supplementation with coconut oil improved intestinal morphology and barrier function, indicated by increased jejunal villus height, as well as enhanced protein expression of ZO-1 and Occludin. Furthermore, coconut oil supplementation improved plasma antioxidant capacity, indicated by enhanced GSH peroxidase activity and decreased malondialdehyde concentration. Moreover, coconut oil ameliorated the LPS-induced release of pro-inflammatory cytokines, as indicated by decreased IL-1\n                    <jats:italic>\u03b2<\/jats:italic>\n                    expression in the jejunum. Coconut oil also alleviated the up-regulation of the expression of necroptosis protein receptor-interacting protein kinase 3 and mixed lineage kinase-like protein in the jejunum of piglets stimulated by LPS. In conclusion, dietary supplementation of coconut oil can improve the growth performance of piglets and alleviate LPS-induced intestinal injury and inflammation by inhibiting necroptosis signalling pathway.\n                  <\/jats:p>","DOI":"10.1017\/s000711452510620x","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T04:10:03Z","timestamp":1766981403000},"page":"795-803","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Coconut oil attenuates intestinal injury and inflammation by regulating necroptosis signalling pathway in lipopolysaccharide-challenged piglets"],"prefix":"10.1017","volume":"135","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0646-7141","authenticated-orcid":false,"given":"Dan","family":"Wang","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05w0e5j23","id-type":"ROR","asserted-by":"publisher"}],"name":"Wuhan Polytechnic 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