{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T07:40:02Z","timestamp":1792568402733,"version":"4.5.0"},"reference-count":30,"publisher":"Cambridge University Press (CUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T00:00:00Z","timestamp":1777248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/tdm\/tdmrep-policy.json"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2026,9,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Plasma levels of procollagen type 1 N-propeptide (P1NP) and C-terminal telopeptide of type 1 collagen (CTX) are bone turnover markers (BTM) used to predict risk of fracture. We compared the effects of vitamin D supplements on plasma levels of P1NP and CTX in the Biochemical Efficacy and Safety Trial of vitamin D (BEST-D) trial (305 participants) after treatment with 2000 IU\/d or 4000 IU\/d vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    or placebo. The results of BEST-D were combined in a meta-analysis of all trials of vitamin D\n                    <jats:italic>v<\/jats:italic>\n                    . placebo on levels of P1NP (12 trials, 2654 participants) or CTX (16 trials, 2695 participants). In BEST-D, allocation to vitamin D\n                    <jats:sub>3<\/jats:sub>\n                    resulted in a dose-dependent increase in 25-hydroxy-vitamin D (25(OH)D) levels but had no effects on P1NP or CTX. Geometric mean (\n                    <jats:sc>se<\/jats:sc>\n                    ) levels at 12 months were similar for P1NP (41\u00b77 (0\u00b77)\n                    <jats:italic>v<\/jats:italic>\n                    . 42\u00b79 (1\u00b70) ng\/ml;\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b729: either dose\n                    <jats:italic>v<\/jats:italic>\n                    . placebo) and likewise for CTX (0\u00b723 (0\u00b701)\n                    <jats:italic>v<\/jats:italic>\n                    . 0\u00b723 (0\u00b701) ng\/ml;\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b798). In a meta-analysis of eighteen trials, the average difference between the within-trial change in P1NP for allocated vitamin D and control was \u22123\u00b73 % (95 % CI \u22125\u00b76, \u22121\u00b70,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b7005). For CTX, this difference was slightly greater (\u22123\u00b78 % (\u22126\u00b78, \u22120\u00b78);\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b701). There was no significant heterogeneity between these trials after stratifying trials with or without Ca, higher or lower doses of vitamin D, or lower\n                    <jats:italic>v<\/jats:italic>\n                    . higher pre-treatment levels of 25(OH)D. Overall, vitamin D supplementation was associated with modest reductions in both P1NP and CTX, and results provide support for further trials of vitamin D for prevention of fracture in older people.\n                  <\/jats:p>","DOI":"10.1017\/s0007114526107193","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T06:30:57Z","timestamp":1777271457000},"page":"536-543","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Effects of vitamin D on biochemical markers of osteoporosis: a meta-analysis of randomised trials"],"prefix":"10.1017","volume":"136","author":[{"given":"Catherine S.","family":"Alber","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Halsey","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Emberson","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold","family":"Hin","sequence":"additional","affiliation":[{"name":"Hightown Surgery"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hill","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane","family":"Armitage","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9802-8241","authenticated-orcid":false,"given":"Robert J.","family":"Clarke","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/052gg0110","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Oxford"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,4,27]]},"reference":[{"key":"S0007114526107193_ref4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0099308"},{"key":"S0007114526107193_ref20","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1000097"},{"key":"S0007114526107193_ref13","doi-asserted-by":"publisher","DOI":"10.1515\/CCLM.2011.602"},{"key":"S0007114526107193_ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s001980070002"},{"key":"S0007114526107193_ref6","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081209"},{"key":"S0007114526107193_ref28","doi-asserted-by":"publisher","DOI":"10.1359\/JBMR.0301244"},{"key":"S0007114526107193_ref18","first-page":"113695","article-title":"Very long-term stability of lipid biomarkers in human serum","volume":"597","author":"Muzakova","year":"2020","journal-title":"Anal Chem"},{"key":"S0007114526107193_ref24","first-page":"3537","article-title":"Early changes in serum N-telopeptide and C-telopeptide cross-linked collagen type 1 predict long-term response to alendronate therapy in elderly women","volume":"85","author":"Greenspan","year":"2000","journal-title":"J Clin Endocrinol Metab"},{"key":"S0007114526107193_ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(03)00168-6"},{"key":"S0007114526107193_ref23","doi-asserted-by":"publisher","DOI":"10.1017\/S002966510800699X"},{"key":"S0007114526107193_ref21","first-page":"l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"20192009","journal-title":"BMJ"},{"key":"S0007114526107193_ref25","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1091"},{"key":"S0007114526107193_ref2","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(01)00614-7"},{"key":"S0007114526107193_ref9","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2019.17789"},{"key":"S0007114526107193_ref29","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1400332"},{"key":"S0007114526107193_ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-016-3833-y"},{"key":"S0007114526107193_ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-014-9842-y"},{"key":"S0007114526107193_ref30","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(00)00248-9"},{"key":"S0007114526107193_ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-012-2049-z"},{"key":"S0007114526107193_ref5","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.081242"},{"key":"S0007114526107193_ref17","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-025-07422-3"},{"key":"S0007114526107193_ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-019-1100-6"},{"key":"S0007114526107193_ref16","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1122"},{"key":"S0007114526107193_ref3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19087"},{"key":"S0007114526107193_ref27","volume-title":"Biochemical Markers of Osteoporosis. StatPearls","author":"Williams","year":"2025"},{"key":"S0007114526107193_ref19","doi-asserted-by":"publisher","DOI":"10.1002\/9780470316696"},{"key":"S0007114526107193_ref8","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.114.086413"},{"key":"S0007114526107193_ref22","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.ED000163"},{"key":"S0007114526107193_ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)68891-0"},{"key":"S0007114526107193_ref7","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-005-1860-1"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114526107193","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114526107193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T06:56:59Z","timestamp":1792565819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114526107193\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9,14]]}},"alternative-id":["S0007114526107193"],"URL":"https:\/\/doi.org\/10.1017\/s0007114526107193","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}