{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T13:39:44Z","timestamp":1785418784781,"version":"3.56.0"},"reference-count":89,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T00:00:00Z","timestamp":1783555200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Diets low in diverse fibre-rich plant foods contribute to the rise of chronic disease. The BIOME study (NCT06231706; 6-week parallel randomised controlled trial) in 399 adults (35\u201365 years; BMI 18\u00b75\u201340 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    ; fibre intake &lt; 20 g\/d) investigated a whole-food plant blend containing &gt; 30 ingredients, rich in (poly)phenols, fibre and micronutrients. Participants were randomised (1:1:1) to the blend (30 g\/d), an isoenergetic control (bread croutons, 28 g\/d) or probiotic (\n                    <jats:italic>Lactobacillus rhamnosus<\/jats:italic>\n                    , 15bn CFU\/d). Analysts were blinded to allocation. The primary outcome was change in \u2018favourable\u2019 and \u2018unfavourable\u2019 gut microbiome species (ZOE Microbiome Health Ranking 2025); secondary outcomes included blood metabolites, symptoms, stool output, anthropometry, hunger, sleep, energy and mood. A crossover sub-study explored postprandial glucose, hunger and mood. Of 349 participants analysed (fifty excluded), self-reported adherence was &gt; 98 %. The 30+ plant blend resulted in more species changing relative abundance at 6 weeks v. control (57\n                    <jats:italic>v.<\/jats:italic>\n                    14 species-level genome bins (SGB),\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b7001) and probiotic (57\n                    <jats:italic>v.<\/jats:italic>\n                    4 SGB,\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b7001). There were no significant between-group differences in microbiome health ranks of significantly changing species (increasing or decreasing). Blend participants self-reported reduced indigestion, constipation, heartburn and flatulence and increased energy\n                    <jats:italic>v<\/jats:italic>\n                    . control (all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b705). Six related but no serious adverse events occurred. In the sub-study, adding the blend to a high-carbohydrate meal (\n                    <jats:italic>v<\/jats:italic>\n                    . meal alone) reduced hunger,\u00a0increased fullness and energy (3-h incremental AUC, all\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b705), with no effect on postprandial glucose. This 30+ plant blend represents a simple strategy to modify gut microbiome composition and benefit gastrointestinal symptoms in healthy adults.\n                  <\/jats:p>","DOI":"10.1017\/s0007114526107703","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T09:15:26Z","timestamp":1783588526000},"page":"1-19","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Does a diverse whole-food plant-based dietary intervention improve gut microbiome composition, gut symptoms, energy and hunger in healthy adults? 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