{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T11:22:52Z","timestamp":1794223372464,"version":"4.8.0"},"reference-count":65,"publisher":"Cambridge University Press (CUP)","issue":"8","license":[{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:00:00Z","timestamp":1781740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/tdm\/tdmrep-policy.json"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2026,10,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Asparagus (Asparagus officinalis) contains bioactive compounds such as polyphenols and saponins, which have been shown to influence cognition, mood, sleep, stress and related biomarkers. However, the evidence from human studies has not been systematically synthesised. To address this, we conducted a systematic review evaluating the effects of asparagus-based products on cognitive, affective, sleep outcomes and related biomarkers in adults. A systematic search of PubMed, Scopus, Web of Science, PsycINFO, Google Scholar and Amino Up Ltd\u2019s website (up to April 2025) identified studies assessing asparagus supplementation in adults, following PRISMA guidelines (PROSPERO registration number: CRD42025636834). Human studies that employed randomised controlled trials or quasi-experimental designs and assessed the effects of orally administered asparagus-based products on cognition, mood, sleep or relevant biomarkers were included. Eighteen studies (thirteen randomised controlled trials and three pre-post-studies; 503 participants) were included. Cognitive improvements were observed in reaction time, accuracy and mental fatigue, while mood and stress-related outcomes showed reductions in anxiety and depressive symptoms. Sleep outcomes consistently demonstrated improvements in sleep quality and duration, while biomarker data showed effects on cortisol levels. Asparagus supplementation may offer modest benefits for cognition, mood and stress-related physiology, with particularly consistent effects on sleep quality. However, the magnitude of benefits varies by population, dose and duration, and the heterogeneity of interventions, small sample sizes and limited studies may constrain the generalisability of findings. Well-powered, long-term clinical trials are needed to determine optimal dosage, clarify mechanisms and assess efficacy across diverse populations.<\/jats:p>","DOI":"10.1017\/s000711452610779x","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T07:42:57Z","timestamp":1781768577000},"page":"948-958","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["The effect of asparagus stem consumption on health outcomes in adults: a systematic review"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5857-0954","authenticated-orcid":false,"given":"Abigail","family":"Davies","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05v62cm79","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Reading"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lamport","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05v62cm79","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Reading"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kohei","family":"Homma","sequence":"additional","affiliation":[{"name":"Amino Up Co Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Takanari","sequence":"additional","affiliation":[{"name":"Amino Up Co Ltd"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-1081","authenticated-orcid":false,"given":"Piril","family":"Hepsomali","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/05v62cm79","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Reading"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,6,18]]},"reference":[{"key":"S000711452610779X_ref50","doi-asserted-by":"publisher","DOI":"10.3390\/medicina58060741"},{"key":"S000711452610779X_ref15","article-title":"Isolation and structure determination of asparagus-derived compounds from ETAS\u00ae","volume":"15","author":"Inoue","year":"2020","journal-title":"Nat Prod Commun"},{"key":"S000711452610779X_ref46","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2008.2962"},{"key":"S000711452610779X_ref30","first-page":"887","article-title":"Effects of food containing asparagus extract (ONR-8) on sleep conditions in evening-type individuals","volume":"44","author":"Kato","year":"2016","journal-title":"Yakuri Chiryo"},{"key":"S000711452610779X_ref13","doi-asserted-by":"publisher","DOI":"10.3390\/nu16142259"},{"key":"S000711452610779X_ref61","first-page":"159","volume-title":"Stress and HPA Axis Dysfunction in Alzheimer\u2019s Disease. 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The Author(s), 2026. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}