{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:55:35Z","timestamp":1793134535958,"version":"4.5.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    This study aimed to investigate whether\n                    <jats:italic>n<\/jats:italic>\n                    -3 PUFA supplementation enhances the anabolic signalling response, muscle hypertrophy and strength gains following resistance training program in healthy young men with habitual protein intake \u22651\u00b76 g\u00b7kg\u207b\n                    <jats:sup>1<\/jats:sup>\n                    \u00b7d\u207b\n                    <jats:sup>1<\/jats:sup>\n                    . In a randomised, double-blind, placebo-controlled trial, forty-six resistance-trained men (28\u00b71 (\n                    <jats:sc>sd<\/jats:sc>\n                    5\u00b78) years, 24\u00b78 (\n                    <jats:sc>sd<\/jats:sc>\n                    3\u00b71) kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    and 1\u00b78 (\n                    <jats:sc>sd<\/jats:sc>\n                    0\u00b75) g\u00b7kg\n                    <jats:sup>\u20131<\/jats:sup>\n                    \u00b7d\n                    <jats:sup>\u20131<\/jats:sup>\n                    protein intake) were assigned to receive either\n                    <jats:italic>n<\/jats:italic>\n                    -3 PUFA (W3; 6\u00b73 g\/d\n                    <jats:italic>n<\/jats:italic>\n                    -3PUFA) or placebo during 14 weeks of supervised lower-limb resistance training 2\u00d7\/week. Body composition, muscle cross-sectional area, maximal dynamic strength (1-RM), muscle tissue fatty acid composition and muscle fibre morphology were assessed pre- and post-intervention. Phosphorylation of mTOR, p70S6K and 4E-BP1 was evaluated at rest and 4-h after exercise, before and after the intervention. Adherence to supplementation and training was high in both groups (&gt;94 %\n                    <jats:italic>n<\/jats:italic>\n                    -3 PUFA supplementation; &gt;96 % training session attendance). A marked incorporation of\n                    <jats:italic>n<\/jats:italic>\n                    -3 PUFA into skeletal muscle (interaction\n                    <jats:italic>P<\/jats:italic>\n                    = 0\u00b7017) was observed in the W3 group. Both groups presented increases in lean mass, strength, rectus femoris and vastus lateralis CSA, vastus lateralis muscle fibre CSA and minimum Feret\u2019s diameter (all main time effects\n                    <jats:italic>P<\/jats:italic>\n                    &lt; 0\u00b705), with no differences between groups. No effects were observed for anabolic signalling between groups or over time (all\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0\u00b705). Overall, despite substantial incorporation into muscle tissue,\n                    <jats:italic>n<\/jats:italic>\n                    -3 PUFA supplementation did not enhance muscle hypertrophy, strength gains or anabolic signalling in healthy adult men with adequate protein intake undergoing resistance training. Future studies should focus on populations with impaired anabolic responses, during periods of disuse or caloric restriction.\n                  <\/jats:p>","DOI":"10.1017\/s0007114526107910","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:44:32Z","timestamp":1783485872000},"page":"1-12","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":1,"title":["Effects of\n                    <i>n<\/i>\n                    -3 PUFA supplementation during resistance training on muscle outcomes in healthy adult men: a randomised clinical trial"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9177-7410","authenticated-orcid":false,"given":"Heloisa","family":"Santo Andre","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wffgt70","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of Campinas"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wagner Ribeiro","family":"Pereira","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovani Boldrini","family":"Custoias","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Oliveira","family":"Bueno","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wffgt70","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of Campinas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Pedro","family":"Marques","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wffgt70","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of Campinas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas Ramires da Silva","family":"Nascimento","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Laura","family":"Vieira","sequence":"additional","affiliation":[{"name":"State University of Campinas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabela Aparecida","family":"Divino","sequence":"additional","affiliation":[{"name":"State University of Campinas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriella Berwig","family":"M\u00f6ller","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiz A. Riani","family":"Costa","sequence":"additional","affiliation":[{"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Jessica","family":"Pinto","sequence":"additional","affiliation":[{"name":"Anschutz Health and Wellness Center, University of Colorado Anschutz Medical Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Giannini","family":"Artioli","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor Luchini","family":"Baptista","sequence":"additional","affiliation":[{"name":"State University of Campinas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamilton","family":"Roschel","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Braga","family":"Benatti","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04wffgt70","id-type":"ROR","asserted-by":"publisher"}],"name":"State University of Campinas"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"},{"id":[{"id":"https:\/\/ror.org\/036rp1748","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Sao Paulo"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,8]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114526107910","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T10:06:56Z","timestamp":1784628416000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114526107910\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,8]]},"references-count":0,"alternative-id":["S0007114526107910"],"URL":"https:\/\/doi.org\/10.1017\/s0007114526107910","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,8]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}