{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T16:17:47Z","timestamp":1785428267329,"version":"3.56.0"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The effect of alcohol consumption on atrial fibrillation risk remains controversial. Evaluating the association of alcohol consumption with atrial fibrillation-related biomarkers may help better understand the relevant mechanistic underpinnings. We studied participants from the PREDIMED-Plus study, a weight-loss randomised trial in metabolically unhealthy adults. N-terminal pro-B-type natriuretic protein, high-sensitivity troponin-T (hsTnT), high-sensitivity C-reactive protein (hsCRP), 3-nitrotyrosine and procollagen type 1 carboxy-terminal propeptide were measured in serum at baseline and years 3 and 5 of follow-up. We calculated average alcohol consumption in drinks\/d (1 drink = 14 grams alcohol) with validated FFQ. Using multivariable models, we estimated cross-sectional and longitudinal associations of alcohol consumption with log-transformed biomarkers. Among 523 participants (mean age (\n                    <jats:sc>sd<\/jats:sc>\n                    ): 65\u00b71 (4\u00b79) years, 40 % female), mean alcohol consumption was 1 drink\/d. Cross-sectionally, alcohol consumption was not associated with cardiac biomarkers. Longitudinally, compared with non-consumers, heavy drinkers at baseline (\u2265 4 drinks\/d) had smaller increases in hsTnT (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    : \u22120\u00b710, 95 % CI: \u22120\u00b720, 0\u00b700) over 5 years. In contrast, those who increased alcohol consumption over follow-up experienced greater increases in hsCRP (\n                    <jats:italic>\u03b2<\/jats:italic>\n                    : 0\u00b731, 95 % CI: 0\u00b700, 0\u00b763) compared with those whose drinking behaviour stayed the same. In this high-risk population, higher baseline alcohol intake was associated with smaller increases in hsTnT over follow-up while increases in alcohol intake over time were associated with higher levels of systemic inflammation. These findings highlight the importance of considering longitudinal changes in average alcohol exposure when evaluating its relationship with cardiometabolic biomarkers.\n                  <\/jats:p>","DOI":"10.1017\/s0007114526107922","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T10:34:31Z","timestamp":1783420471000},"page":"1-8","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Association of alcohol consumption with circulating biomarkers of atrial fibrillation-related pathways in a population at high cardiometabolic risk"],"prefix":"10.1017","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-4447","authenticated-orcid":false,"given":"Aniqa B.","family":"Alam","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estefan\u00eda","family":"Toledo Atucha","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute (ISCIII)"},{"name":"Navarra Institute for Health Research"},{"name":"University of Navarra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dora","family":"Romaguera","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute (ISCIII)"},{"name":"Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel M.","family":"Alonso-G\u00f3mez","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute (ISCIII)"},{"name":"Araba University Hospital, University of the Basque Country UPV\/EHU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3917-9808","authenticated-orcid":false,"given":"Miguel Angel","family":"Mart\u00ednez-Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute (ISCIII)"},{"name":"Navarra Institute for Health Research"},{"name":"University of Navarra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Tojal-Sierra","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute (ISCIII)"},{"name":"Araba University Hospital, University of the Basque Country UPV\/EHU"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3480-2645","authenticated-orcid":false,"given":"Cristina","family":"Razquin","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute (ISCIII)"},{"name":"Navarra Institute for Health Research"},{"name":"University of Navarra"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Noris","family":"Mora","sequence":"additional","affiliation":[{"name":"Health Research Institute of the Balearic Islands (IdISBa), Palma de Mallorca"},{"name":"Hospital Universitari Son Espases"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linzi","family":"Li","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinita","family":"Subramanya","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2700-7459","authenticated-orcid":false,"given":"Jordi","family":"Salas-Salvad\u00f3","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute (ISCIII)"},{"name":"Rovira i Virigili University"},{"name":"Institut de Recerca Biom\u00e8dica Catalunya Sud (IRB-CatSud)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Fito Colomer","sequence":"additional","affiliation":[{"name":"Carlos III Health Institute (ISCIII)"},{"name":"Hospital del Mar Medical Research Institute (IMIM)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alvaro","family":"Alonso","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/03czfpz43","id-type":"ROR","asserted-by":"publisher"}],"name":"Emory University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,7,7]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114526107922","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T07:24:42Z","timestamp":1785309882000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114526107922\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,7]]},"references-count":0,"alternative-id":["S0007114526107922"],"URL":"https:\/\/doi.org\/10.1017\/s0007114526107922","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,7]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives licence (https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided that no alterations are made and the original article is properly cited. The written permission of Cambridge University Press or the rights holder(s) must be obtained prior to any commercial use and\/or adaptation of the article.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}