{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T12:50:32Z","timestamp":1791291032259,"version":"4.3.0"},"reference-count":35,"publisher":"Cambridge University Press (CUP)","issue":"4","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The aim of this study was to provide robust evidence on the long-term use of non-nutritive sweetened (NNS) beverages on weight management, by comparing NNS beverages and water during 1 year of assisted weight management followed by a voluntary, unassisted 1-year extension. In this parallel-group, open-label, controlled equivalence trial, 493 adults with BMI 27\u201335 kg\/m\n                    <jats:sup>2<\/jats:sup>\n                    who regularly consumed cold beverages were randomised 1:1 to water (\n                    <jats:italic>n<\/jats:italic>\n                    246) or NNS beverages (\n                    <jats:italic>n<\/jats:italic>\n                    247). Participants joined a group behavioural weight-management programme comprising assisted meetings weekly (12-week weight-loss phase) then monthly (40-week weight-maintenance phase), followed by unassisted monitoring for 52 weeks with a final meeting at week 104. The final 52-week unassisted phase was completed by 220 participants (water:\n                    <jats:italic>n<\/jats:italic>\n                    117; NNS beverages:\n                    <jats:italic>n<\/jats:italic>\n                    103), 27\u00b77 % of whom were NNS beverage-na\u00efve (na\u00efve was defined as NNS beverages comprising \u2264 25 % of beverages in the 5 years before screening). In the unassisted monitoring phase, the primary endpoint was weight change from baseline at week 104 (equivalence: two-sided\n                    <jats:italic>P<\/jats:italic>\n                    &gt; 0\u00b705). Participants consuming water maintained a weight loss of 3\u00b77 kg over 104 weeks, compared with 4\u00b78 kg with NNS beverages; the between-group difference was not significant. After the final 52-week unassisted phase of the 104-week behavioural weight-management programme, water and NNS beverages showed equivalence regarding weight change from baseline. Our findings suggest people can lose weight and maintain it for 2 years, when drinking either NNS beverages or water and taking part in weight-management programmes.\n                  <\/jats:p>\n                  <jats:p>This trial is registered with ClinicalTrials.gov: NCT02591134.<\/jats:p>","DOI":"10.1017\/s0007114526108150","type":"journal-article","created":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T02:58:13Z","timestamp":1785812293000},"page":"482-493","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Effect of non-nutritive sweetened beverages\n                    <i>v<\/i>\n                    . water on body weight: long-term results of a randomised controlled trial"],"prefix":"10.1017","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-4586","authenticated-orcid":false,"given":"Joanne A.","family":"Harrold","sequence":"first","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xs57h96","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Hill","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xs57h96","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Radu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xs57h96","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Thomas","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xs57h96","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Thorp","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xs57h96","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte A.","family":"Hardman","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xs57h96","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Christiansen","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xs57h96","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Una","family":"Masic","sequence":"additional","affiliation":[{"name":"Ministry of Defence"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauren","family":"McGale","sequence":"additional","affiliation":[{"name":"Edge Hill University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan J.","family":"Cuthbertson","sequence":"additional","affiliation":[{"name":"University of Liverpool"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason C.G.","family":"Halford","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/04xs57h96","id-type":"ROR","asserted-by":"publisher"}],"name":"University of Liverpool"},{"name":"University of Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"S0007114526108150_ref24","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23796"},{"key":"S0007114526108150_ref7","unstructured":"7. 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Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (https:\/\/creativecommons.org\/licenses\/by\/4.0\/), which permits unrestricted re-use, distribution and reproduction, provided the original article is properly cited.","name":"license","label":"License","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}