{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T09:09:59Z","timestamp":1788772199973,"version":"build-2803163510"},"reference-count":0,"publisher":"Cambridge University Press (CUP)","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":["cambridge.org"],"crossmark-restriction":true},"short-container-title":["Br J Nutr"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Prospective evidence linking overall diet quality to gastroesophageal reflux disease (GERD) is limited, and metabolic pathways remain unclear. In a cohort of 183\u00a0878 adults free of GERD at baseline, we examined nine dietary pattern scores derived from repeated 24-h dietary recalls and assessed associations with incident GERD over a median follow-up of 13\u00b72 years, during which 15\u00a0401 cases occurred. Higher adherence to healthy patterns including Mediterranean diet, Mediterranean-Dietary Approaches to Stop Hypertension Diet Intervention for Neurodegenerative Delay, Dietary Approaches to Stop Hypertension and dietary index for gut microbiota was associated with lower GERD risk (highest\n                    <jats:italic>v<\/jats:italic>\n                    . lowest tertile hazard ratios 0\u00b787\u20130\u00b789), whereas a pro-inflammatory pattern (Energy-adjusted Diet Inflammatory Index) was linked to higher risk (hazard ratio 1\u00b711). In a metabolomics sub-cohort (\n                    <jats:italic>N<\/jats:italic>\n                    98\u00a0669), diet-related NMR metabolomic signatures, derived from 168 biomarkers using Elastic Net regression, reflected similar associations and mediated 11\u00b71\u201332\u00b72 % of the diet\u2013GERD relationship. Associations were largely consistent across subgroups and robust in sensitivity analyses, supporting a potential role of systemic metabolic profiles in mediating the effects of diet on GERD and highlighting metabolic mechanisms underlying diet-related disease risk.\n                  <\/jats:p>","DOI":"10.1017\/s0007114526108162","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T07:09:00Z","timestamp":1786000140000},"page":"1-13","update-policy":"https:\/\/doi.org\/10.1017\/policypage","source":"Crossref","is-referenced-by-count":0,"title":["Dietary patterns, metabolomics and incident gastroesophageal reflux disease: a prospective cohort study"],"prefix":"10.1017","author":[{"given":"Lei","family":"Zhang","sequence":"first","affiliation":[{"name":"Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunhui","family":"Ma","sequence":"additional","affiliation":[{"name":"Nantong First People\u2019s Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Chen","sequence":"additional","affiliation":[{"name":"Nantong University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Huang","sequence":"additional","affiliation":[{"name":"Zunyi Medical University - Zhuhai Campus"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Long","sequence":"additional","affiliation":[{"name":"Jinhua Municipal Center for Disease Control and Prevention"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2386-1503","authenticated-orcid":false,"given":"Fulan","family":"Hu","sequence":"additional","affiliation":[{"id":[{"id":"https:\/\/ror.org\/01vy4gh70","id-type":"ROR","asserted-by":"publisher"}],"name":"Shenzhen University School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2026,8,6]]},"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114526108162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T08:38:41Z","timestamp":1788770321000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114526108162\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":0,"alternative-id":["S0007114526108162"],"URL":"https:\/\/doi.org\/10.1017\/s0007114526108162","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"assertion":[{"value":"\u00a9 The Author(s), 2026. Published by Cambridge University Press on behalf of The Nutrition Society","name":"copyright","label":"Copyright","group":{"name":"copyright_and_licensing","label":"Copyright and Licensing"}}]}}