{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T10:47:33Z","timestamp":1790333253925,"version":"4.1.0"},"reference-count":21,"publisher":"Cambridge University Press (CUP)","issue":"1","license":[{"start":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T00:00:00Z","timestamp":1187740800000},"content-version":"unspecified","delay-in-days":3339,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1998,7]]},"abstract":"<jats:p><jats:italic>Agrimony eupatoria<\/jats:italic>(agrimony) has been documented as a traditional treatment of diabetes. Here, the effects of dietary administration of agrimony on streptozotocin (STZ)-diabetic mice and on in vitro glucose uptake and glucose metabolism, and on insulin secretion by BRIN-BD11 cells were investigated. Agrimony incorporated into the diet (62\u00b75 g\/kg) and drinking water (2\u00b75 g\/l) countered the weight loss, polydipsia, hyperphagia and hyperglycaemia of STZ-diabetic mice. Aqueous extract of agrimony (1 mg\/ml) stimulated 2-deoxy-glucose transport (1\u00b74-fold), glucose oxidation (1\u00b74-fold) and incorporation of glucose into glycogen (2\u00b70-fold) in mouse abdominal muscle comparable with 0\u00b71 \u03bcM-insulin. In acute 20 min tests, 0\u00b725-1 mg\/ml aqueous extract of agrimony evoked a stepwise 1\u00b79\u20133\u00b78-fold stimulation of insulin secretion from the BRIN-BD11 pancreatic B-cell line. This effect was abolished by 0\u00b75mM-diazoxide and previous exposure to extract did not adversely affect subsequent stimulation of insulin secretion by 10 mM-L-alanine, thereby indicating that there was no detrimental effect of the extract on cell viability. The effect of extract was glucose-independent and was not evident in BRIN-BD11 cells exposed to a depolarizing concentration of KCl. The ability of agrimony extract to enhance insulin secretion was dependent on use of heat during extract preparation. These results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in<jats:italic>Agrimony eupatoria<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0007114598001834","type":"journal-article","created":{"date-parts":[[2007,8,22]],"date-time":"2007-08-22T08:54:17Z","timestamp":1187772857000},"page":"109-114","source":"Crossref","is-referenced-by-count":66,"title":["Actions of the traditional anti-diabetic plant,<i>Agrimony eupatoria<\/i>(agrimony): effects on hyperglycaemia, cellular glucose metabolism and insulin secretion"],"prefix":"10.1017","volume":"80","author":[{"given":"Alison M.","family":"Gray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Flatt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"56","published-online":{"date-parts":[[2007,8,22]]},"reference":[{"key":"S0007114598001834_ref020","doi-asserted-by":"publisher","DOI":"10.1021\/jf60209a056"},{"key":"S0007114598001834_ref019","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1079\/PNS19910077","article-title":"Traditional dietary adjuncts for the treatment of diabetes mellitus","volume":"50","author":"Day","year":"1991","journal-title":"Proceedings of the Nutrition Society"},{"key":"S0007114598001834_ref017","doi-asserted-by":"publisher","DOI":"10.1016\/0009-8981(71)90332-9"},{"key":"S0007114598001834_ref014","first-page":"387","volume-title":"Nutrient Regulation of Insulin Secretion","author":"Okamoto","year":"1992"},{"key":"S0007114598001834_ref013","doi-asserted-by":"publisher","DOI":"10.2337\/diab.45.8.1132"},{"key":"S0007114598001834_ref008","doi-asserted-by":"publisher","DOI":"10.1079\/PNS19970051"},{"key":"S0007114598001834_ref007","first-page":"147","article-title":"Failure of glucose tolerance factor-containing brewer's yeast to ameliorate spontaneous diabetes in C57\/KsJ db\/db mice","volume":"10","author":"Flatt","year":"1989","journal-title":"Diabetes Research"},{"key":"S0007114598001834_ref006","doi-asserted-by":"publisher","DOI":"10.1007\/BF00252768"},{"key":"S0007114598001834_ref005","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5250.813"},{"key":"S0007114598001834_ref004","first-page":"153","volume-title":"Frontiers of Insulin Secretion and Pancreatic B-cell Research","author":"Dunne","year":"1994"},{"key":"S0007114598001834_ref021","unstructured":"World Health Organization (1980) Second Report of the WHO Expert Committee on Diabetes Mellitus. Technical Report Series no. 646, p. 66. 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Studies in normal and streptozotocin diabetic mice","volume":"33","author":"Day","year":"1990","journal-title":"Diabetologia"},{"key":"S0007114598001834_ref011","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0168-8227(93)90128-R","article-title":"Nicotinamide, a poly (ADP-ribose) synthetase inhibitor, ameliorates B-cell function in partially depancreatized rats","volume":"22","author":"Tanigawa","year":"1993","journal-title":"Diabetes Research and Clinical Practice"},{"key":"S0007114598001834_ref001","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.12.8.553"},{"key":"S0007114598001834_ref016","first-page":"1574","article-title":"Effects of nicotinamide supplementation on human pancreatic-islet function in tissue culture","volume":"77","author":"Sandler","year":"1993","journal-title":"Journal of Clinical Endocrinology and Metabolism"}],"container-title":["British Journal of Nutrition"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.cambridge.org\/core\/services\/aop-cambridge-core\/content\/view\/S0007114598001834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,8,22]],"date-time":"2021-08-22T04:36:19Z","timestamp":1629606979000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.cambridge.org\/core\/product\/identifier\/S0007114598001834\/type\/journal_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998,7]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1998,7]]}},"alternative-id":["S0007114598001834"],"URL":"https:\/\/doi.org\/10.1017\/s0007114598001834","relation":{},"ISSN":["0007-1145","1475-2662"],"issn-type":[{"value":"0007-1145","type":"print"},{"value":"1475-2662","type":"electronic"}],"subject":[],"published":{"date-parts":[[1998,7]]}}}