{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T23:30:10Z","timestamp":1780702210197,"version":"3.54.1"},"reference-count":26,"publisher":"Cambridge University Press (CUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,9]],"date-time":"2007-03-09T00:00:00Z","timestamp":1173398400000},"content-version":"unspecified","delay-in-days":2930,"URL":"https:\/\/www.cambridge.org\/core\/terms"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Br J Nutr"],"published-print":{"date-parts":[[1999,3]]},"abstract":"<jats:p><jats:italic>Coriandrum sativum<\/jats:italic>(coriander) has been documented as a traditional treatment of diabetes. In the present study, coriander incorporated into the diet (62\u00b75 g\/kg) and drinking water (2\u00b75 g\/l, prepared by 15 min decoction) reduced hyperglycaemia of streptozotocin-diabetic mice. An aqueous extract of coriander (1 mg\/ml) increased 2-deoxyglucose transport (1\u00b76-fold), glucose oxidation (1\u00b74-fold) and incorporation of glucose into glycogen (1\u00b77-fold) of isolated murine abdominal muscle comparable with 10<jats:sup>\u22128<\/jats:sup>m-insulin. In acute 20 min tests, 0\u00b725\u201310 mg\/ml aqueous extract of coriander evoked a stepwise 1\u00b73\u20135\u00b77-fold stimulation of insulin secretion from a clonal B-cell line. This effect was abolished by 0\u00b75 mm-diazoxide and prior exposure to extract did not alter subsequent stimulation of insulin secretion by 10 mm-l-alanine, thereby negating an effect due to detrimental cell damage. The effect of extract was potentiated by 16\u00b77 mm-glucose and 10 mm-l-alanine but not by 1 mm-3-isobutyl-1-methylxanthine. Insulin secretion by hyperpolarized B-cells (16\u00b77 mm-glucose, 25 mm-KCl) was further enhanced by the presence of extract. Activity of the extract was found to be heat stable, acetone soluble and unaltered by overnight exposure to acid (0\u00b71 m-HCl) or dialysis to remove components with molecular mass &lt; 2000 Da. Activity was reduced by overnight exposure to alkali (0\u00b71 m-NaOH). Sequential extraction with solvents revealed insulin-releasing activity in hexane and water fractions indicating a possible cumulative effect of more than one extract constituent. These results demonstrate the presence of antihyperglycaemic, insulin-releasing and insulin-like activity in<jats:italic>Coriandrum sativum<\/jats:italic>.<\/jats:p>","DOI":"10.1017\/s0007114599000392","type":"journal-article","created":{"date-parts":[[2012,1,24]],"date-time":"2012-01-24T09:48:17Z","timestamp":1327398497000},"page":"203-209","source":"Crossref","is-referenced-by-count":149,"title":["Insulin-releasing and insulin-like activity of the traditional anti-diabetic plant<i>Coriandrum sativum<\/i>(coriander)"],"prefix":"10.1017","volume":"81","author":[{"given":"Alison M.","family":"Gray","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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